Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.120 CausalMutation CLINVAR

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.460 CausalMutation CLINVAR ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. 1654209

1991
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 CausalMutation CLINVAR Effects of marine oil-enriched diets on guinea pig megakaryocyte and platelet lipids: effects on thromboxane synthesis and platelet function. 2302402

1990
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR rac, a novel ras-related family of proteins that are botulinum toxin substrates. 2674130

1989
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells. 3004741

1986
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR The ras gene family and human carcinogenesis. 3283542

1988
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR ras genes. 3304147

1987
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus. 6287572

1982
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus. 6287573

1982
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses. 6288698

1982
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.460 CausalMutation CLINVAR Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. 6587382

1984
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR RAS signalling is abnormal in a c-raf1 MEK1 double mutant. 7651428

1995
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers. 9598803

1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. 10555148

1999
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.180 GeneticVariation CLINVAR Role of the switch II region in the conformational transition of activation of Ha-ras-p21. 10716188

2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. 11504908

2001
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.460 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919

2002
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.460 CausalMutation CLINVAR BRAF mutations in papillary carcinomas of the thyroid. 14508525

2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 GeneticVariation CLINVAR Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9. 14681681

2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. 14688025

2004
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.500 CausalMutation CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963

2004