×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.
24723567
2014
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases.
23415889
2013
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma.
22811390
2013
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles.
23409019
2013
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases.
22691310
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.
22994785
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
A risk of essential thrombocythemia in carriers of constitutional CHEK2 gene mutations.
22058216
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.
23109706
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Frequency of the CHEK2 1100delC mutation among women with early-onset and bilateral breast cancer.
22520019
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.
23329222
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
CHEK2*1100delC and risk of malignant melanoma: Danish and German studies and meta-analysis.
21956126
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women.
22058428
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
22006311
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer.
21876083
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.
21244692
2011
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer.
20722467
2010
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Synergistic interaction of variants in CHEK2 and BRCA2 on breast cancer risk.
19030985
2009
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
CHEK2 1100delC and male breast cancer in the Netherlands.
18759107
2009
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
CHEK2 is a multiorgan cancer susceptibility gene.
15492928
2004
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.
11967536
2002
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.
11719428
2001
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Nephroblastoma
0.100
CausalMutation
CLINVAR
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
10617473
1999