Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.300 Therapeutic CTD_human Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart. 11309296

2001
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C1383860
Disease: Cardiac Hypertrophy
Cardiac Hypertrophy 		0.300 Therapeutic CTD_human Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart. 11309296

2001
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.310 Biomarker CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560

2017
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.350 Biomarker CTD_human Differential induction of Mn-containing superoxide dismutase by paraquat in peripheral lymphocytes of normal subjects and gastric cancer patients. 14503839

2003
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.300 Biomarker CTD_human Differential induction of Mn-containing superoxide dismutase by paraquat in peripheral lymphocytes of normal subjects and gastric cancer patients. 14503839

2003
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker CTD_human Differential induction of Mn-containing superoxide dismutase by paraquat in peripheral lymphocytes of normal subjects and gastric cancer patients. 14503839

2003
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.310 Biomarker CTD_human Mechanism of cross-resistance to cisplatin in a mitomycin C-resistant human bladder cancer cell line. 7729958

1995
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.310 Biomarker CTD_human Mechanism of cross-resistance to cisplatin in a mitomycin C-resistant human bladder cancer cell line. 7729958

1995
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.310 Biomarker CTD_human Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade. 17363595

2007
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.340 Biomarker CTD_human Metallothionein is up-regulated under hypoxia and promotes the survival of human prostate cancer cells. 17914565

2007
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.340 Therapeutic CTD_human Metallothionein is up-regulated under hypoxia and promotes the survival of human prostate cancer cells. 17914565

2007
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Therapeutic CTD_human Metallothionein is up-regulated under hypoxia and promotes the survival of human prostate cancer cells. 17914565

2007
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Biomarker CTD_human Metallothionein is up-regulated under hypoxia and promotes the survival of human prostate cancer cells. 17914565

2007
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.340 Therapeutic CTD_human Metallothionein isoform II expression in hyperplastic, dysplastic and neoplastic prostatic lesions. 16574721

2006
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.340 Biomarker CTD_human Metallothionein isoform II expression in hyperplastic, dysplastic and neoplastic prostatic lesions. 16574721

2006
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Biomarker CTD_human Metallothionein isoform II expression in hyperplastic, dysplastic and neoplastic prostatic lesions. 16574721

2006
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Therapeutic CTD_human Metallothionein isoform II expression in hyperplastic, dysplastic and neoplastic prostatic lesions. 16574721

2006
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0282612
Disease: Prostatic Intraepithelial Neoplasias
Prostatic Intraepithelial Neoplasias 		0.300 Biomarker CTD_human Metallothionein isoform II expression in hyperplastic, dysplastic and neoplastic prostatic lesions. 16574721

2006
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0403447
Disease: Chronic Kidney Insufficiency
Chronic Kidney Insufficiency 		0.300 Biomarker CTD_human Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies. 27122239

2016
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.310 Biomarker CTD_human Metallothionein-1 and -2 expression in cadmium- or arsenic-derived human malignant urothelial cells and tumor heterotransplants and as a prognostic indicator in human bladder cancer. 16565513

2006
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.310 Biomarker CTD_human Metallothionein-1 and -2 expression in cadmium- or arsenic-derived human malignant urothelial cells and tumor heterotransplants and as a prognostic indicator in human bladder cancer. 16565513

2006
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness 		0.300 Biomarker CTD_human Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells. 21187089

2011
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.300 Biomarker CTD_human MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. 25070658

2014
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.300 Therapeutic CTD_human Modulation of cytochrome C oxidase-va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity. 16144979

2005
Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014