|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
To determine the mutation status of human telomerase reverse transcriptase gene (TERT) promoter region in hepatocellular carcinoma (HCC) from different geographical regions.
|
25574106 |
2015 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Here we identified the frequency of mutations in telomerase reverse transcriptase (TERT) promoter was 34% in non-clear cell HCC (NCCHCC, n = 259) and 26.3% in clear cell HCC (CCHCC, n = 57).
|
28460432 |
2017 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
The current study provided the characteristics of genetic aberrations in NAFLD-HCC and suggested that TERT promoter mutations and chromosome 8p loss mainly contribute to NAFLD-related liver carcinogenesis.
|
27511114 |
2016 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
K19<sup>+</sup> HCC had TERT promoter mutations less frequently than K19<sup>-</sup> HCC (31% versus 59%; P = 0.022), and lacked alterations in KRAS and IDH1.
|
31017316 |
2019 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we demonstrate a substantial role for the rs2853669 in HCC with TERT promoter mutation, which suggests that the combination of the rs2853669 and the mutation indicate poor prognoses in liver cancer.
|
26575952 |
2016 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
TERT promoter mutations were highly frequent in glioblastoma (83.9%), urothelial carcinoma (64.5%), oligodendroglioma (70.0%), medulloblastoma (33.3%) and hepatocellular carcinoma (31.4%).
|
25843513 |
2015 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
These data show that TERT promoter mutation is the most frequent genetic alteration in hepatocellular carcinoma known at this time.
|
25267585 |
2014 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Here, we investigated the occurrence and implications of genetic alterations in the TERT promoter in hepatitis B viral hepatocellular carcinoma (B viral HCC).
|
29987895 |
2018 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
HCC cases associated to factors other than hepatitis viruses are also frequently mutated in TERT promoter (43.6%, 52.6% and 57.7% in USA, Asia and Europe, respectively).
|
28529542 |
2017 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
An identical CTNNB1 mutation was identified in the 1996 liver tumor together with a TERT promoter mutation showing that this hepatocellular carcinoma results from the malignant transformation of the initial β-catenin inflammatory adenoma.
|
27984126 |
2017 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
TERT promoter mutations were consistently identified in both HCC and CC components, supporting TERT alteration as an early event in CHC evolution.
|
30690729 |
2019 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Finally, integrative analysis of HCAs transformed to hepatocellular carcinoma revealed β-catenin mutation as an early alteration and TERT promoter mutations as associated with the last step of the adenoma-carcinoma transition.
|
24735922 |
2014 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Atypical hepatocellular neoplasm and hepatocellular carcinoma also demonstrated largely similar genomic profiles, but TERT promoter mutations were restricted to hepatocellular carcinoma (21%) and copy number alterations were more common in hepatocellular carcinoma (64 vs 31%).
|
31189995 |
2019 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Our study demonstrates the importance of CTNNB1 mutations and NFE2L2-KEAP1 pathway activation in HB development and defines loss of genomic stability and TERT promoter mutations as prominent characteristics of aggressive HB with HCC features.
|
25135868 |
2014 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Cyclin-driven HCC display a unique signature of structural rearrangements with hundreds of tandem duplications and templated insertions frequently activating TERT promoter.
|
30531861 |
2018 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
TERT promoter mutations were highly related to the step-wise hepatocarcinogenesis because mutations were identified in 6% of LGDNs, 19% of HGDNs, 61% of eHCCs, and 42% of small and progressed HCC.
|
25123086 |
2014 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Thirty percent of HCCs harbored TERT promoter mutations and there was a significant difference in rs2736098 and rs2736100 genotypes between wt and mutant TERT promoter-bearing HCC tumors (P = 0.007 and 0.018, respectively).
|
28416747 |
2017 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
TERT promoter mutations (10.5%) and broad copy-number aberrations in chromosomes 1 and 8 (3-7%) were identified as trunk gatekeepers in DNs and were maintained in sHCCs.
|
28843658 |
2017 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Conclusion: TERT elevation by AR through integrated HBV and point mutation at the TERT promoter region was identified as a mechanism for the male dominance of HBV-related HCCs; telomerase and AR thus may be targets for intervention of HCC.
|
30070724 |
2019 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Detection of TERT promoter mutations in those with low levels of AFP may aid diagnosis of HCC with atypical presentation.
|
27056898 |
2016 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
In hepatitis B surface antigen (HBs Ag)-positive HCC without TERT promoter mutations, HBV integration into TERT locus was found in 47% patients and was mutually exclusive to TERT promoter mutations.
|
26553052 |
2016 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
Our results showed aberrant methylation of the UTSS region of the TERT promoter in HCC (mean=15.1) compared with the adjacent normal tissues (mean=6.1, P<0.00001).
|
25683523 |
2015 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
These data demonstrated that TERT promoter mutation is a frequent event in HCC; however, telomere length, but not the presence of a TERT promoter mutation, might have potential value as a prognostic indicator of HCC.
|
28151853 |
2017 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
We assayed mutations in the TERT promoter region by Sanger sequencing and used next-generation sequencing to analyze the entire coding regions of 7 well-characterized HCC driver genes-based on shared or discordant mutations in these genes, we classified the HCCs in each patient as IM, MC, or indeterminate.
|
29180252 |
2018 |
|
LOC110806263
|
Liver carcinoma
|
0.100 |
GeneticVariation |
BEFREE |
TERT promoter and CTNNB1 mutations were only observed in hepatocellular carcinomas but not in precursor lesions.
|
27661004 |
2016 |