×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
Biomarker
GENOMICS_ENGLAND
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
UNIPROT
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
CausalMutation
CLINVAR
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
CLINVAR
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
Biomarker
CTD_human
4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.
21967605 2011
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
Colorectal cancers commonly carry truncation mutations in the adenomatous polyposis coli (APC ) gene.22399804 2012
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
Biomarker
BEFREE
CRC is a very heterogeneous disease, and with a few exceptions (APC , p53, KRAS), most of the genes involved in CRC are observed in a small percentage of cases.24944469 2014
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
Colorectal cancer (CRC ) is a multistep process based on the accumulation of somatic mutations in genes such as APC and KRAS.26749281 2016
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
Biomarker
BEFREE
Colorectal cancers show evidence of Wnt signaling pathway activation and this is associated with loss of function of the tumor regulator APC .29169144 2018
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
Colorectal cancers (CRC s) initiate through distinct mutations, including in APC pathway components leading to tubular adenomas (TAs); in BRAF, with epigenetic silencing of CDX2, leading to serrated adenomas (SAs); and in the DNA mismatch repair machinery driving microsatellite instability (MSI).30716341 2019
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
Colorectal cancer (CRC ) development is characterized by the stepwise accumulation of mutations over time, of which mutations in the tumor suppressor APC are often very early to occur.30799131 2020
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
Colorectal cancer is a complex disease driven by well-established mutations such as APC and other yet to be identified pathways.31213502 2019
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC gene mutations have been demonstrated not only in colorectal carcinoma but also in a variety of human cancers.10381126 1998
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC mutation was not correlated with previous history of colorectal carcinoma or number of polyps.10502830 1999
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews.11159880 2001
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC mutation and tumour budding in colorectal cancer .12499439 2003
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC and K- ras mutations are considered to be early-stage developments of CRC s, whereas p53 mutations are thought to be relatively late events in the tumorigenesis of CRC s.15185002 2004
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
PosttranslationalModification
BEFREE
APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q.15326380 2004
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
PosttranslationalModification
BEFREE
APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer .16981189 2006
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
Biomarker
BEFREE
Adenomatous polyposis coli (APC ) protein is a large tumor suppressor that is truncated in most colorectal cancers .17293347 2007
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC mutations cause activation of Wnt/beta-catenin signaling, which invariably leads to colorectal cancer .20663899 2010
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
AlteredExpression
BEFREE
APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation.23773491 2013
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
Biomarker
BEFREE
APC (Min/+)-Cdx2 mutants recapitulated several aspects of human colorectal cancer , including an invasive phenotype.25320087 2014
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC mutations (APC -mt) occur in ∼70% of colorectal cancers (CRC s), but their relationship to prognosis is unclear.26305864 2015
×
Entrez Id: 324
Gene Symbol: APC
APC
Colorectal Carcinoma
0.800
GeneticVariation
BEFREE
APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC ) and these mutations cooperatively accelerate tumorigenesis including metastasis.27835580 2016