×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
Hereditary Diffuse Gastric Cancer
0.800
Biomarker
CTD_human
As the finding of pathogenic CDH1 mutations is useful for management of HDGC families, screening for deletions should be offered to at-risk families.
19168852
2009
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
Hereditary Diffuse Gastric Cancer
0.800
Biomarker
CTD_human
Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa.
19184424
2010
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
Hereditary Diffuse Gastric Cancer
0.800
Biomarker
CTD_human
Direct evidence of E-cadherin mutations triggering tumorigenesis has come from the finding of inactivating germline mutations of the gene (CDH1 ) in hereditary diffuse gastric cancer (HDGC ).
12588804
2003
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
Hereditary Diffuse Gastric Cancer
0.800
Biomarker
CTD_human
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
24816253
2014
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
Hereditary Diffuse Gastric Cancer
0.800
Biomarker
CTD_human
We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations.
10072428
1999
×
Entrez Id:
999
Gene Symbol:
CDH1
CDH1
Hereditary Diffuse Gastric Cancer
0.800
Biomarker
CTD_human
E-cadherin germline mutations in familial gastric cancer.
9537325
1998
×
Entrez Id:
3557
Gene Symbol:
IL1RN
IL1RN
Hereditary Diffuse Gastric Cancer
0.500
Biomarker
CTD_human
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Hereditary Diffuse Gastric Cancer
0.400
Biomarker
CTD_human
Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
11397402
2001
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Hereditary Diffuse Gastric Cancer
0.400
Biomarker
CTD_human
DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene.
10874023
2000
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Hereditary Diffuse Gastric Cancer
0.360
Biomarker
CTD_human
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.
22484628
2012
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Hereditary Diffuse Gastric Cancer
0.360
Biomarker
CTD_human
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
24816253
2014
×
Entrez Id:
4595
Gene Symbol:
MUTYH
MUTYH
Hereditary Diffuse Gastric Cancer
0.320
Biomarker
CTD_human
×
Entrez Id:
324
Gene Symbol:
APC
APC
Hereditary Diffuse Gastric Cancer
0.320
Biomarker
CTD_human
×
Entrez Id:
4609
Gene Symbol:
MYC
MYC
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis.
17171786
2006
×
Entrez Id:
4609
Gene Symbol:
MYC
MYC
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.
21173787
2012
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.
21173787
2012
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
21364753
2011
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
22042947
2011
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Therapeutic
CTD_human
"Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells."
15723263
2005
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
"Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells."
15723263
2005
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Therapeutic
CTD_human
Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.
21173787
2012
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Therapeutic
CTD_human
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
22042947
2011
×
Entrez Id:
1496
Gene Symbol:
CTNNA2
CTNNA2
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
24816253
2014
×
Entrez Id:
2023
Gene Symbol:
ENO1
ENO1
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Diverse proteomic alterations in gastric adenocarcinoma.
15378696
2004
×
Entrez Id:
5480
Gene Symbol:
PPIC
PPIC
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
16367923
2006