Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk. 20431935

2010

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs14133) genotypes were distributed differently between the prostate cancer and control groups. 21273602

2011

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE A comprehensive search was conducted to identify all case-control studies of COX-2 rs2745557 polymorphism and PCa risk. 22435969

2012

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE We showed that EGFR and COX-2 expression was higher in metastatic than non-metastatic PCa tissues and cells. 24155892

2013

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE Although it is low in stromal and tumor cells, COX-2 expression is induced by TNF-alpha in these cells, and this responsiveness may play an important role in prostate cancer progression. 11289153

2001

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE COX-2 gene promoter haplotypes and prostate cancer risk. 14754878

2004

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort. 22023987

2011

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker BEFREE Overall, these results provide strong evidence for the role of COX-2 and Glut-1 proteins for the progression of prostate cancer and highlighting the potential of celecoxib and genistein as a useful and combinatorial pharmacological agent for chemotherapeutic purposes in prostate cancer. 30673592

2019

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE All-NSAIDs use was inversely associated with prostate cancer: OR 0.77, 95% CI 0.61-0.98, especially in men using NSAIDs that preferentially inhibit COX-2 activity (OR 0.48, 95% CI 0.28-0.79). 28941222

2017

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE In conclusion, NFKB1 -94 ins/del and COX-2 (-1195G>A) polymorphisms may be, respectively, associated with decreased and increased prostate cancer risk in the Chinese population. 26788504

2015

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker BEFREE COX-2 staining was positive in the cytoplasm of prostate cancer cells. 19836060

2011

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker BEFREE Moreover, results showed that COX-2 overexpression or a COX-2 product Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) caused an increase in matriptase activation and PCa cell invasion, whereas COX-2 silencing antagonized matriptase activation and cell invasion. 28368394

2017

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker BEFREE To elucidate the effects of COX-2 on p53 in response to hypoxia, we transfected the COX-2 gene into the p53-positive, COX-2-negative MDA-PCa-2b human prostate cancer cell line. 15550400

2005

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker BEFREE COX-2 might play an important role in the progress of PCa, overexpression of COX-2 correlates with T3-T4 stages of PCa. 23053989

2012

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE Therefore, this feedback loop may be relevant in prostate cancer for the maintenance of PGE<sub>2</sub> -dependent cancer cell growth through amplifying the activity of the COX-2 pathway. 30367494

2019

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE We have identified CREB-mediated activation of Cox-2 as a potential signaling pathway in prostate cancer which can be blocked with a nontoxic, cost-effective dietary supplement like Nexrutine, demonstrating a prospective for development of Nexrutine for prostate cancer management. 18030357

2007

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE Since increased Cox-2 expression is associated with an increased incidence of prostate cancer, and decrease in its expression by SPBE would provide a basis for further investigation of its use against BPH and in prostatic cancer chemoprevention. 11913955

2001

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE We examined whether sequence variants in the COX-2 gene are associated with prostate cancer risk. 16506214

2006

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxide synthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and prostate cancers. 19965896

2010

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE Enforced expression of miR-101 inhibits prostate cancer cell growth by modulating the COX-2 pathway in vivo. 21430074

2011

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE COX-2 was positively expressed in AIPC and ADPC, which were predominantly in endochylema of prostate cancer (PCa) cells. 18645679

2008

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression BEFREE 8-CPT-2Me-cAMP treatment caused a 2-2.5-fold increase of p-cPLA2(S505), COX-2, and PGE2 levels in human prostate cancer cell lines. 23646189

2013

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker BEFREE Treatment with the COX-2 inhibitors celecoxib and CAY10404 or knockdown of COX-2 significantly inhibited prostate cancer cell proliferation. 24802614

2014

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker BEFREE The expression of Ki-67, PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for BCR in patients with clinically localized prostate cancer following radical prostatectomy. 27232854

2018

Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE The importance of HIF-1alpha in tumor progression makes it a logical target for chemoprevention strategies in patients at higher genetic risk of breast and prostate cancer with Cox 2 inhibitors or 2-methoxyestradiol, as well as a target for new approaches to inhibiting angiogenesis. 16954428

2006