Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. 31754293

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE In addition, miR-34a expression was negatively related to HDAC1 expression. miR-34a mimic was transfected into HCC cell lines (HepB3 and HepG2). 28123637

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE The strategies to increase miR-34a level might be a critical targeted therapy for HCC in future. 23593387

2013

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Rubone activated miR34a expression in HCC cells with wild-type or mutated p53 but not in cells with p53 deletions. 25217526

2014

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE We sought to develop inorganic-organic hybrid vehicle for the systemic delivery of the tumor suppressor miR-34a, and to investigate the efficiency of the delivered miR-34a in the treatment of HCC in vitro and in vivo. 31701846

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE CA9 expression levels were also correlated with miR-34a levels and rs1048638 genotypes in HCC patients. rs1048638 influences HCC risk and progression through effects on miR-34a-targeted CA9 expression in HCC. 28667334

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Here, we describe a hepatocellular carcinoma (HCC) cell-based luciferase reporter system which could be used to screen for small molecule modulators of tumor suppressor microRNA-34a. 27924482

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE We found that miR-34a expression was significantly downregulated in HCC tissues (P<0.05). 27879964

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Previous studies have focused on the association of miR-34 family members with carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). 23935875

2013

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Numerous studies have focused on the association between miR-34 family members, which are direct p53 targets, and carcinogenesis of many cancers, including hepatocellular carcinoma (HCC). 23632240

2013

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE In contrast, there was a negative correlation between levels of microRNA 34a and lincRNA-UFC1 in HCC tissues; microRNA 34a reduced the stability of lincRNA-UFC1. 25449213

2015

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Here, we found that the expression of microRNA-34a-5p (miR-34a-5p) was significantly decreased in patients with hepatitis B virus (HBV)-activated liver fibrosis and HCC, as well as in CC14 (Carbon tetrachloride Tetrachloromethane) induced liver fibrosis model mice. 29957876

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE We suggest that patients diagnosed with HCC with β-catenin mutations could be treated with an inhibitor of miR-34a. 25792709

2016

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE MiR-34a expression was also down-regulated in HCCs compared with corresponding non-cancerous hepatic tissues. 28667294

2017

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Moreover, in vitro and in vivo studies showed that exo-circ-DB promotes HCC growth and reduces DNA damage via the suppression of miR-34a and the activation of deubiquitination-related USP7. 30546088

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Since miR-122 and miR-34a downregulation is a common feature in spontaneous human hepatocarcinoma, our finding that these miRNAs are able to target FUT8 3'UTR suggests that, together with transcriptional and other post-transcriptional systems, a miRNA-mediated mechanism could also be involved in the increased core fucosylation observed in liver tumors. 24130780

2013

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE In the present study, the expression of miR‑34a in human liver cancer tissues and cell lines was evaluated and the effects of miR‑34a on cell proliferation, invasion and glycolysis in hepatocellular carcinoma (HCC) cells were determined. 29328457

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Finally, we introduce methods to study TGF-β-regulated miRNAs and their functions in tumor progression and metastasis using an example of publication from our lab demonstrating the presence of a TGF-β-miR-34a-CCL22 signaling axis, which serves as a potent etiological pathway for the development of hepatocellular carcinoma venous metastases. 26520135

2016

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Therefore, the results of the present study may improve understanding regarding the role of miR-34a in regulating cell proliferation and contribute to the development of novel therapy of HCC. 30627547

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Erratum: microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma. 31807195

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 PosttranslationalModification BEFREE In this study, we investigated the methylation status of miR-34 family in HCC tumor and adjacent non-tumor tissues using methylation-specific PCR (MSP). 24704024

2014

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE This study aimed to investigate the relationship of a functional variant (rs1057317) at microRNA-34a (miR-34a) binding site in toll-like receptor 4 gene and the risk of hepatocellular carcinoma. 25179842

2014

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE To confirm effect of miR-34a-5p on tumor growth and its possible effect on MCM2, miR-34a-5p mimic and inhibitor was transfected into HCC cell lines (HepG2). 31034943

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE Expression Analysis of Serum microRNA-34a and microRNA-183 in Hepatocellular Carcinoma 30256056

2018

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Kaplan-Meier survival curves were used to analyze the associations of miR-34a, <i>E2F1</i> and <i>E2F3</i> expression and overall survival in HCC. 31114344

2019