Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE The concentrations of interferon (IFN)-β, interleukin (IL)-6, and tumor necrosis factor-α in MM cell culture supernatants were detected with respective commercial ELISA kits. 29214775

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma? 22387051

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE Loss-of-function mutations in genes encoding the signaling protein tumor necrosis factor receptor-associated factor 3 (TRAF3) are commonly found in human B-cell malignancies, especially multiple myeloma and B-cell lymphoma (BCL). 29296923

2017

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression BEFREE Noteworthy, a significant inverse correlation of differentially expressed pro-apoptotic genes was observed in pre-MM: overexpression of Fas and TNF-α and underexpression of YY1 versus expression of anti-apoptotic genes in MM: overexpression of YY1 and underexpression of Fas and TNF-α. 28476134

2017

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE In conclusion, blockage of JAK/STAT-mediated NF- κ B activation was highly effective in controlling the growth of MM cells and, consequently, an inhibitor of TNF α -mediated IL-6 secretion would be a potential new therapeutic agent for patients with multiple myeloma. 24151609

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE Sub-group analysis also confirmed that no evidence supported the relevance of TNF-α promoter -238/-308 gene polymorphisms with MM. 22999526

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE The aim of this study was to examine the involvement of the tumor necrosis factor-ligand family member, receptor activator of nuclear factor-kappaB ligand (RANKL), and its naturally occurring antagonist, osteoprotegerin (OPG), in MM biology. 14500379

2003

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression BEFREE Studies have shown that enhanced TNF-alpha levels in myeloma patients correlated with aggressive disease. 15041705

2004

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE For genes in which linkage disequilibrium was observed between multiple loci, MM risk was positively associated with the haplotype block covering part of the LTA*TNF complex (LTA -82C/-90G *TNF -1036C/-487G/-417G, OR = 1.63, 95% CI 1.02-2.16) compared with the most frequently occurring haplotype observed among controls (LTA -82A/-90A *TNF -1036C/-487G/-417G). 17315188

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE In conclusion, the NOS3 (+894) TT and TNF α(-308) GG genotypes may have roles in myeloma pathogenesis. 27039718

2016

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE Several autocrine soluble factors, including macrophage inflammatory protein-1α (MIP-1α), tumor necrosis factor-α, and hepatocyte growth factor, promote cell survival and growth in multiple myeloma (MM) cells. 29057477

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression BEFREE Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma. 17927494

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE Similarly, marrow stromal cells from p62(-/-) mice produced much lower levels of IL-6, tumor necrosis factor-alpha (TNF-alpha), and receptor activator of NF-kappaB ligand (RANKL) and supported MM cell growth and osteoclast formation to a much lower extent than normal cells. 19282458

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE Agents which act to inhibit TNFalpha may therefore abrogate the paracrine growth and survival advantage conferred by MM cell adhesion in the BM microenvironment. 11494147

2001

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE The results of the present study indicate that complement and coagulation-associated genes, the complement and coagulation cascades pathway, EDN1, let-7e, let-7b-5p, miR-19a, and the tumor necrosis factor and HIF-1 signaling pathways may all be implicated in MM and MGUS. 28943924

2017

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression BEFREE Moreover, CSL when administered either alone or in combination with bortezomib inhibited MM tumor growth and decreased serum IL-6 and TNF-α levels. 29773987

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE MM patients carrying the GA genotype (P=0.01) or GA+AA genotypes (P=0.02) at the TNF-α -308 polymorphism were associated with a reduced risk for MM. 20122728

2010

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE Our results indicate that the cytokine (IL-6, TNF-alpha and IL-1beta) and IL-Ra gene polymorphisms do not confer susceptibility to the development of MM. 10848780

2000

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression BEFREE CD70 is a TNF superfamily member whose normal expression is highly restricted but is aberrantly expressed in hematologic malignancies including non-Hodgkin lymphoma (NHL), Hodgkin disease, and multiple myeloma. 17038522

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE These findings suggest that regulatory polymorphisms of the TNF-alpha gene can affect TNF-alpha production and predict the outcome after Thal therapy, particularly in those MM pts who are genetically defined as "high producers" of TNF-alpha. 12200397

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE We demonstrate that myeloma stimulates osteoclastogenesis by triggering a coordinated increase in the tumor necrosis factor-related activation-induced cytokine (TRANCE) and decrease in its decoy receptor, osteoprotegerin (OPG). 11562486

2001

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 Biomarker BEFREE Knock-down of XBP1 in MM patient BMSCs greatly compromised their increased VCAM-1 protein expression and IL-6 and RANKL secretion in response to TNFα and reversed their enhanced support of MM-cell growth and osteoclast formation. 22427205

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 GeneticVariation BEFREE In the present study we investigated the association of deletion polymorphisms in <i>GSTT1/GSTM1</i> genes and single nucleotide polymorphisms (SNPs) in the <i>TNF-</i>α gene at positions -308/-238 with the risk and outcome in MM and sensitivity to bortezomib under <i>in vitro</i> conditions. 31681592

2019

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression BEFREE We discovered that among several myeloma growth/survival factors tested (including IL6, oncostatin M, insulin-like growth factor 1, tumor necrosis factor α and IFNα) IFNγ was the strongest inducer of BCL6 mRNA and protein expression in MM cell lines. 29510136

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.100 AlteredExpression BEFREE B-cell maturation antigen (BCMA), a tumor necrosis factor receptor (TNFR) family member, is selectively expressed on terminally differentiated B-lymphocytes including multiple myeloma (MM) tumor cells. 31035033

2019