×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
HPO
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
LHGDN
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
17936563 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
LHGDN
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance.
17911267 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
BRCA1-associated breast tumors display loss of BRCA1 and frequent somatic mutations of PTEN and TP53.
22628410 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
Cowden disease, an autosomal dominant harmartoma syndrome associated with thyroid and breast tumors , has been found to be associated with mutations of PTEN /MMAC1 gene.
10741010 2000
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
10555148 1999
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
BEFREE
Depleting Cdh1 accelerates breast cancer cell proliferation and cooperates with PTEN loss to promote breast tumor progression in mice.
31420536 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
AlteredExpression
LHGDN
Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer.
16436456 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
LHGDN
Dysregulated PTEN-PKB and negative receptor status in human breast cancer.
12569575 2003
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.
11504908 2001
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
18787170 2008
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
Genotype-phenotype association analyses have revealed that the presence of germline PTEN mutations is associated with breast tumor development, and that mutations occurring within and 5' of the phosphatase motif were associated with multi-organ involvement.
12938083 2003
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
LHGDN
IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells.
17369847 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
AlteredExpression
BEFREE
Importantly, USP13 protein is downregulated in human breast tumours and correlates with PTEN protein levels.
24270891 2013
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
GeneticVariation
BEFREE
In this study, we predicted and analyzed the impact of three deleterious coding non-synonymous single nucleotide polymorphisms rs121909218 (rs121909218 " genes_norm="5728">G129E ), rs121909229 (R130Q ) and rs57374291 (rs57374291 " genes_norm="5728">D107N) in the PTEN gene on the phenotype of breast tumors using computational tools SIFT, Polyphen-2, PROVEAN, MUPro, POPMusic and the GETAREA server.
27221918 2016
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
BEFREE
In vivo, administering miR-21 antisense oligonucleotides restored trastuzumab sensitivity in the resistant breast cancer xenografts by inducing PTEN expression, whereas injection of miR-21 mimics conferred trastuzumab resistant in the sensitive breast tumors via PTEN silence.
21471222 2011
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
AlteredExpression
LHGDN
Investigate the role of PTEN in chemotaxis of human breast cancer cells.
17761400 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
LHGDN
Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein.
17178862 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
Biomarker
CTD_human
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality.
19685490 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
PosttranslationalModification
LHGDN
PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney.
17669465 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
PosttranslationalModification
BEFREE
Presence of PTEN promoter methylation (39.44 %) significantly correlated with its expression downregulation (45.56 %) in breast tumors (P = 0.0001).
26754093 2016
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
PosttranslationalModification
LHGDN
Promoter methylation of the PTEN gene is a common molecular change in breast cancer.
15287024 2004
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
AlteredExpression
LHGDN
PTEN regulates phospholipase D and phospholipase C.
17405772 2007