×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.
7530509
1995
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.
7530509
1995
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
9438854
1998
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
9438854
1998
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours.
11276010
2001
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours.
11276010
2001
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.
16046538
2005
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.
15790786
2005
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.
15790786
2005
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Somatic activation of KIT in distinct subtypes of melanoma.
16908931
2006
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Somatic activation of KIT in distinct subtypes of melanoma.
16908931
2006
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Detection of c-kit exons 11- and 17-activating mutations in testicular seminomas by high-resolution melting amplicon analysis.
16741525
2006
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
In this study, we investigated a group of anal melanomas for the presence of BRAF, NRAS, KIT and PDGFRA mutations.
17372901
2007
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
In this study, we investigated a group of anal melanomas for the presence of BRAF, NRAS, KIT and PDGFRA mutations.
17372901
2007
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
KIT mutations were detected in 23% (3 of 13) of acral melanomas , 15.6% (7 of 45) of mucosal melanomas , 7.7% (1 of 13) of conjunctival melanomas , 1.7% (1 of 58) of cutaneous melanomas , and 0% (0 of 60) of choroidal melanomas .
18980976
2008
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib.
18936790
2008
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Major response to imatinib mesylate in KIT-mutated melanoma.
18421059
2008
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation.
18510589
2008
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
KIT mutations were detected in 23% (3 of 13) of acral melanomas , 15.6% (7 of 45) of mucosal melanomas , 7.7% (1 of 13) of conjunctival melanomas , 1.7% (1 of 58) of cutaneous melanomas , and 0% (0 of 60) of choroidal melanomas .
18980976
2008
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.
18955458
2008
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation.
18510589
2008
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
19671763
2009
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
GeneticVariation
CLINVAR
Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene.
19812602
2010
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy--case report and review of the literature.
19996579
2010
×
Entrez Id:
3815
Gene Symbol:
KIT
KIT
melanoma
0.500
CausalMutation
CLINVAR
Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene.
19812602
2010