Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C2675128
Disease: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6 (finding)
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6 (finding) 		0.300 Biomarker CTD_human

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Therapeutic CTD_human Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion. 8215636

1993
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion. 8215636

1993
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.320 Biomarker CTD_human Thus, elevations of MnSOD mRNA levels in lung or BAL may be predictive of lung disease. 8063194

1994
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.310 Biomarker CTD_human Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. 7744320

1995
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0030246
Disease: Pustulosis of Palms and Soles
Pustulosis of Palms and Soles 		0.300 Biomarker CTD_human Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. 7744320

1995
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.350 Biomarker CTD_human ALS specimens from the motor cortex and the spinal cord presented enhanced SOD-2 immunoreactivity, especially of astrocytes and occasionally of neurons. 8866423

1996
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker CTD_human Enhanced superoxide dismutase-2 immunoreactivity of astrocytes and occasional neurons in amyotrophic lateral sclerosis. 8866423

1996
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0543859
Disease: Amyotrophic Lateral Sclerosis, Guam Form
Amyotrophic Lateral Sclerosis, Guam Form 		0.300 Biomarker CTD_human Enhanced superoxide dismutase-2 immunoreactivity of astrocytes and occasional neurons in amyotrophic lateral sclerosis. 8866423

1996
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0007621
Disease: Neoplastic Cell Transformation
Neoplastic Cell Transformation 		0.300 Therapeutic CTD_human Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells. 9067545

1997
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0007621
Disease: Neoplastic Cell Transformation
Neoplastic Cell Transformation 		0.300 Biomarker CTD_human Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells. 9067545

1997
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.300 Biomarker CTD_human Down-regulation of manganese-superoxide dismutase gene expression in idiopathic nephrotic syndrome. 9152291

1997
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.320 Biomarker CTD_human Manganese superoxide dismutase in healthy human pleural mesothelium and in malignant pleural mesothelioma. 9533946

1998
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0027540
Disease: Necrosis
Necrosis 		0.300 Therapeutic CTD_human Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms. 9548797

1998
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0027540
Disease: Necrosis
Necrosis 		0.300 Biomarker CTD_human Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms. 9548797

1998
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0268255
Disease: Farber Lipogranulomatosis
Farber Lipogranulomatosis 		0.310 Biomarker CTD_human Markedly higher expression of mRNA, protein, and activity of MnSOD in skin fibroblasts from patients with Farber disease, a human disorder with pathognomonic accumulation of ceramide due to a deficiency of ceramidase, than in normal skin fibroblasts indicate that ceramide may act as a physiological inducer of MnSOD gene expression. 10428046

1999
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0751651
Disease: Mitochondrial Diseases
Mitochondrial Diseases 		0.310 Biomarker CTD_human Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice. 9917329

1999
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0949855
Disease: Electron Transport Chain Deficiencies, Mitochondrial
Electron Transport Chain Deficiencies, Mitochondrial 		0.300 Biomarker CTD_human Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice. 9917329

1999
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0949856
Disease: Oxidative Phosphorylation Deficiencies
Oxidative Phosphorylation Deficiencies 		0.300 Biomarker CTD_human Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice. 9917329

1999
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0949857
Disease: Mitochondrial Respiratory Chain Deficiencies
Mitochondrial Respiratory Chain Deficiencies 		0.300 Biomarker CTD_human Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice. 9917329

1999
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.370 Biomarker CTD_human Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. 10853026

2000
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.360 Biomarker CTD_human Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. 10853026

2000
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.330 Biomarker CTD_human Mitochondrial adaptations to obesity-related oxidant stress. 10860543

2000
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.320 Biomarker CTD_human Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma. 11053990

2000
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.320 Biomarker CTD_human Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma. 11053990

2000