×
Entrez Id: 3567
Gene Symbol: IL5
IL5
Degenerative polyarthritis
0.030
Biomarker
BEFREE
<b>Abbreviations used:</b> MIA: Monosodium iodoacetate; i.ar: Intra-articular; OA: Osteoarthritis ; TRF : Turmerosaccharides rich fraction; TLF: Turmerosaccharides less fraction; PGE2: Prostaglandin E2; ROS: Reactive oxygen species.
29142423 2017
×
Entrez Id: 7200
Gene Symbol: TRH
TRH
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations used:</b> MIA: Monosodium iodoacetate; i.ar: Intra-articular; OA: Osteoarthritis ; TRF : Turmerosaccharides rich fraction; TLF: Turmerosaccharides less fraction; PGE2: Prostaglandin E2; ROS: Reactive oxygen species.
29142423 2017
×
Entrez Id: 7013
Gene Symbol: TERF1
TERF1
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations used:</b> MIA: Monosodium iodoacetate; i.ar: Intra-articular; OA: Osteoarthritis ; TRF : Turmerosaccharides rich fraction; TLF: Turmerosaccharides less fraction; PGE2: Prostaglandin E2; ROS: Reactive oxygen species.
29142423 2017
×
Entrez Id: 1800
Gene Symbol: DPEP1
DPEP1
Degenerative polyarthritis
0.420
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenene; ATG7: autophagy-related 7; ATP: adenosine triphosphate; BafA1: bafilomycin A<sub>1</sub>; BMDMs: bone marrow derived macrophages; CHX: cycloheximide; DMM: destabilization of the medial meniscus; ELISA: enzyme-linked immunosorbent assay; GFP: green fluorescent protein; IL1B/IL-1β: interleukin 1 beta; LIPUS: low-intensity pulsed ultrasound; LIR: LC3-interacting region; LPS: lipopolysaccharide; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MDP : muramyl dipeptide; NFKB/NF-κB: nuclear factor kappa B; NLRP3: NLR family, pyrin domain containing 3; OA : osteoarthritis; PKM/PKM2: pyruvate kinase M1/2; PMA: phorbol-12-myristate-13-acetate; PYCARD/ASC; PYD and CARD domain containing; RFP: red fluorescent protein; siRNAs: small interfering RNAs; SQSTM1: sequestosome 1; TEM: transmission electron microscopy.
31500508 2019
×
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
Degenerative polyarthritis
0.100
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenene; ATG7: autophagy-related 7; ATP: adenosine triphosphate; BafA1: bafilomycin A<sub>1</sub>; BMDMs: bone marrow derived macrophages; CHX: cycloheximide; DMM: destabilization of the medial meniscus; ELISA: enzyme-linked immunosorbent assay; GFP: green fluorescent protein; IL1B/IL-1β: interleukin 1 beta; LIPUS: low-intensity pulsed ultrasound; LIR: LC3-interacting region; LPS: lipopolysaccharide; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MDP: muramyl dipeptide; NFKB/NF-κB: nuclear factor kappa B; NLRP3: NLR family, pyrin domain containing 3 ; OA : osteoarthritis; PKM/PKM2: pyruvate kinase M1/2; PMA: phorbol-12-myristate-13-acetate; PYCARD/ASC; PYD and CARD domain containing; RFP: red fluorescent protein; siRNAs: small interfering RNAs; SQSTM1: sequestosome 1; TEM: transmission electron microscopy.
31500508 2019
×
Entrez Id: 26269
Gene Symbol: FBXO8
FBXO8
Degenerative polyarthritis
0.020
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS : fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 64319
Gene Symbol: FBRS
FBRS
Degenerative polyarthritis
0.020
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS : fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 706
Gene Symbol: TSPO
TSPO
Degenerative polyarthritis
0.010
GeneticVariation
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS : phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 55638
Gene Symbol: SYBU
SYBU
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 55177
Gene Symbol: RMDN3
RMDN3
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 151393
Gene Symbol: RMDN2
RMDN2
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 51115
Gene Symbol: RMDN1
RMDN1
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 1131
Gene Symbol: CHRM3
CHRM3
Degenerative polyarthritis
0.010
GeneticVariation
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS : phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 115908
Gene Symbol: CTHRC1
CTHRC1
Degenerative polyarthritis
0.020
Biomarker
BEFREE
<b>Conclusion:</b> Our studies show that CTHRC1 is a sensitive and easy-to-measure plasma marker that differentiates between RA and healthy status and also distinguishes between RA and other forms of arthritis, such as OA and ReA.
31249576 2019
×
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
<b>Methods:</b> Human primary chondrocytes from OA patients or healthy donors and human chondrogenic SW1353 cells were cultured and stimulated with IL-1β in vitro, the mRNA expressions and protein levels of MMP-13, ADAMTS-4, ADAMTS-5, SENP1, and SENP2 were determined using real time PCR and Western blot, respectively.
31372032 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Degenerative polyarthritis
0.100
Biomarker
BEFREE
<b>Methods:</b> We used polymerase chain reaction (PCR) method to identify the expression levels of Cyclin D1 and down-stream Wnt/β-catenin pathway-related genes in OA chondrocytes according to the grade of OA .
31155960 2019
×
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
Degenerative polyarthritis
0.100
Biomarker
BEFREE
<b>Objectives:</b> The aim of our study was to evaluate the role of NLRP3, IL-1β, and IL-1α in the menisectomy (MNX) model of murine OA .
28659793 2017
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Degenerative polyarthritis
0.050
Biomarker
BEFREE
<b>Results:</b> Cyclin D1 was significantly decreased with OA grade (<i>p</i> < .05).
31155960 2019
×
Entrez Id: 960
Gene Symbol: CD44
CD44
Degenerative polyarthritis
0.090
Biomarker
BEFREE
<b>Results:</b> Compared with age-matched CBA mice, 4-/8-month-old STR/Ort mice had cartilage lesions and their CSPCs exhibited lower proliferative and differentiation capacity (decreased CD44 and CD90), and identified 7082 DE RNAs in STR/Ort mice were associated with strain differences or OA progression.
30775942 2019
×
Entrez Id: 7070
Gene Symbol: THY1
THY1
Degenerative polyarthritis
0.020
Biomarker
BEFREE
<b>Results:</b> Compared with age-matched CBA mice, 4-/8-month-old STR/Ort mice had cartilage lesions and their CSPCs exhibited lower proliferative and differentiation capacity (decreased CD44 and CD90 ), and identified 7082 DE RNAs in STR/Ort mice were associated with strain differences or OA progression.
30775942 2019
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Degenerative polyarthritis
0.100
Biomarker
BEFREE
<b>Results:</b> FSGTC treatment significantly relieved the degeneration of cartilage and reduced the contents of tumor necrosis factor-α (TNF-α ) and IL-6 in the serum in papain-induced OA rats.
30174601 2018
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Degenerative polyarthritis
0.100
Biomarker
BEFREE
<b>Results:</b> FSGTC treatment significantly relieved the degeneration of cartilage and reduced the contents of tumor necrosis factor-α (TNF-α) and IL-6 in the serum in papain-induced OA rats.
30174601 2018
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Degenerative polyarthritis
0.400
Biomarker
BEFREE
<b>Results:</b> Our results showed that a proinflammatory cytokine interleukin-1β induced the OA model and desumoylation of aggrecan and collagen type II because the small ubiquitin-like modifier 2/3 (SUMO2/3) was co-localized with aggrecan and collagen type II proteins and interacted physically with them.
31372032 2019
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Degenerative polyarthritis
0.100
Biomarker
BEFREE
<b>Results:</b> The results of ELISA (IL-1β and tumor necrosis factor-α ), the histological evaluation (Mankin and OARSI score), western blotting [COL2A1, matrix metalloproteinase (MMP)-3, MMP-13, IL-1β, and nuclear factor-kappaB (NF-κB) p65], and immunohistochemistry (COL2A1, MMP-3, and MMP-13) indicated that oral CAR attenuated the development of T2DM-induced OA and suppressed the inflammatory response.
29928231 2018
×
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
Degenerative polyarthritis
0.500
Biomarker
BEFREE
<b>Results:</b> The results of ELISA (IL-1β and tumor necrosis factor-α), the histological evaluation (Mankin and OARSI score), western blotting [COL2A1 , matrix metalloproteinase (MMP)-3, MMP-13, IL-1β, and nuclear factor-kappaB (NF-κB) p65], and immunohistochemistry (COL2A1, MMP-3, and MMP-13) indicated that oral CAR attenuated the development of T2DM-induced OA and suppressed the inflammatory response.
29928231 2018