Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE The increased expression of ADAM17 may play a key role in the development of HCC. 15309730

2004

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Therefore, as compared to sequential 3-DCRT, EVBT combined with portal vein stenting and TACE improved overall survival of HCC patients with main portal vein tumor thrombus. 28076848

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE No significant differences were observed in survival status or disease progression between cTACE and DEB-TACE in patient subgroups with either tumor number > 5 or with the sum of the diameter of largest five HCC tumors being > 7 cm. 30075752

2018

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Patients in DS group can achieve post-transplant survival and HCC recurrence-free probability, at five years, just like patients within MC in patients undergoing DEB-TACE. 31602168

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Survival analyses and Cox regression models revealed that TACE and a combination therapy of TACE and sorafenib were significant prognostic factors in metastatic HCC. 28797231

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE A prognosis and impact factor analysis of DC-CIK cell therapy for patients with hepatocellular carcinoma undergoing postoperative TACE. 29400599

2018

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Conventional TACE is safe and effective for huge HCCs, but has limited effects in cases with four or more tumors. 30907468

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Volumetric pre-TACE enhancement on MRI and post-TACE oil deposition in CT may accurately predict necrosis in treated HCC lesions. 29383518

2018

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE <b>Conclusions:</b> Adjuvant TACE does not improve the DFS of HCC patients with tumor size less than 5 cm. 31079496

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE The aim of the study was to correlate tumor stiffness (TS) measured with MR elastography (MRE) with degree of tumor enhancement and necrosis on contrast-enhanced T1-weighted imaging (CE-T1WI) in hepatocellular carcinomas (HCC) treated with Yttrium-90 radioembolization (RE) or transarterial chemoembolization plus radiofrequency ablation (TACE/RFA). 28154910

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents. 31611551

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE The aim of this study was to determine whether pro-inflammatory cytokines elevated in patients with hepatocellular carcinoma influence fractalkine shedding from HepG2 cells and whether ADAM17 was involved in this process. 20922190

2010

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE High ADAM17 and active integrin β1 levels in tumor tissues were significantly associated with poor survival of HCC patients. 29966664

2018

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Our retrospective study could not reveal a difference in toxicity and efficiency between cTACE and DEB-TACE for treatment of advanced stage HCC with PVT. 27277261

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE <b>Conclusions</b>: We identified risk factors for extrahepatic progression after TACE in HCC patients. 31598173

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE CalliSpheres Drug-Eluting Bead Transcatheter Arterial Chemoembolization Presents With Better Efficacy and Equal Safety Compared to Conventional TACE in Treating Patients With Hepatocellular Carcinoma. 30862264

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE 24 patients (54-79 years) undergoing P-CT before and shortly after DEB-TACE of HCC were prospectively included in this dual-center study. 28629564

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE MicroRNA-145 inhibits cell proliferation by directly targeting ADAM17 in hepatocellular carcinoma. 25174729

2014

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE DEB-TACE and <sup>90</sup>Y-radioembolization are efficacious treatments for patients suffering from HCC; DEB-TACE demonstrated survival benefit at 1-year compared to <sup>90</sup>Y-radioembolization but direct comparison is warranted for further evaluation. 27562480

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE In this study, we show that MSC migration to HCC can be effectively inhibited by TACE and γ-secretase inhibitors that stop the activation of EpCAM signaling event. 28903370

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE Retrospective, cohort study of 51 patients treated with DEB-TACE for unresectable HCC was studied: 23 with 100-300 μm particles and 28 with 70-150 μm particles. 31709778

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE A systematic review was conducted to identify trials about curative treatment combined with or without adjuvant therapies (interferon, IFN; or transarterial chemoembolization, TACE) for HCC. 29163828

2017

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. 30824840

2019

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker BEFREE The correlation between the number of small HCCs detected by immediate lipiodol CT and the size of HCC lesions (diameter >1 cm) diagnosed preoperatively was analyzed 1 month after TACE. 30334525

2018

Entrez Id: 6868
Gene Symbol: ADAM17
ADAM17
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation BEFREE We prospectively included a cohort of 14 patients with diagnosis of HCC who were treated with local ablative therapy (transarterial chemoembolization, TACE and/or radiofrequency ablation, RFA). 29444164

2018