Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker CTD_human Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. 22450443

2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker CTD_human Tumor necrosis factor alpha (TNF) and interleukin-1 (IL-1) production by alveolar macrophages (AM) was evaluated in 17 rheumatoid arthritis (RA) patients without interstitial lung disease (ILD, Group 1) and 14 RA patients with clinical ILD (Group 2) in comparison with 10 control subjects. 2001072

1991
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker CTD_human Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid. 12566094

2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker CTD_human TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy. 8391952

1993
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0006625
Disease: Cachexia
Cachexia 		0.600 Biomarker CTD_human Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention. 17878525

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.600 Biomarker CTD_human Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine. 22119283

2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.600 Biomarker CTD_human Altered expression of innate immunity genes in different intestinal sites of children with ulcerative colitis. 20452301

2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.600 Biomarker CTD_human Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves. 19617644

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker CTD_human Protective effects of chronic resveratrol treatment on vascular inflammatory injury in streptozotocin-induced type 2 diabetic rats: Role of NF-kappa B signaling. 24513509

2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018790
Disease: Cardiac Arrest
Cardiac Arrest 		0.600 Biomarker CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674

1998
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 Biomarker CTD_human Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4. 15231041

2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 Biomarker CTD_human Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor. 18034274

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 Biomarker CTD_human TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure. 29959987

2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 Biomarker CTD_human Heart failure may in fact be accentuated by a downregulation of myocardial TNF-alpha. 15135663

2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 Biomarker CTD_human Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the pathogenesis of heart failure. 17337591

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.600 Biomarker CTD_human TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure. 29959987

2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.600 Biomarker CTD_human Although patients with advanced congestive heart failure express elevated circulating levels of tumour necrosis factor-alpha (TNFalpha), little is known about the prognostic importance and regulation of TNF in the heart in cardiac disease states. 15231041

2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.600 Biomarker CTD_human Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor. 18034274

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.600 Biomarker CTD_human Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the pathogenesis of heart failure. 17337591

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.600 Biomarker CTD_human Heart failure may in fact be accentuated by a downregulation of myocardial TNF-alpha. 15135663

2004
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker CTD_human Neither of these inhibitors, however, affected tumor necrosis factor alpha, prostaglandin E2 or epinephrine hyperalgesia. 16472913

2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker CTD_human Thus, increased sensitization and up-regulation of TRPV1 constitutes a potential mechanism by which TNFalpha mediates inflammatory hyperalgesia and pain. 18582539

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker CTD_human Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition. 26141506

2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker CTD_human Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism. 17320857

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker CTD_human Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia. 10401557

1999