Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. 21220474

2011

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 GeneticVariation BEFREE A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features. 23728071

2013

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE These results demonstrated that miR-1246 inhibited cell invasion and EMT process by targeting CXCR4 and blocking JAK/STAT and PI3K/AKT signal pathways in lung cancer cells. 29171984

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE The results show that lutein inhibits the PI3K/AKT signaling pathway and induces apoptosis in A549, which may therefore be used as a potent natural anticancer drug with no side effects to treat lung cancer. 30806240

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 GeneticVariation BEFREE Genetic variants in PI3K/AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapy. 26645682

2016

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 AlteredExpression BEFREE We demonstrated that regulation of JNK/ P38/PI3K by TGF-β1 led to down expression of NMII-A which promoted EMT and lung cancer metastasis. 28782471

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 GeneticVariation BEFREE Here, we focused on Akt kinase-interacting protein1 (Aki1), a scaffold protein of PI3K (phosphoinositide 3-kinase)/PDK1 (3-phosphoinositide-dependent protein kinase)/Akt that determines receptor signal selectivity for non-mutated EGFR, and assessed its role in EGFR mutant lung cancer with or without gatekeeper T790M mutation. 23045273

2013

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Taken together, these findings demonstrate that PI3K/AKT/YY1 is involved in the regulation of lung cancer cell behavior induced by IL‑13, and miR‑29a represents a promising therapeutic target. 29620222

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE The mechanism may involve of PI3K/AKT signaling pathways in A549 cells, which may a potential therapeutic target for the treatment of lung cancer. 30344755

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Dual molecular targeted therapy for mTOR and PI3K may be a promising therapeutic strategy in the specific population of patients with lung cancer with LKB1 loss. 30825612

2019

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE These findings have important implications for developing effective PI3K/mTOR inhibitor-based therapies for lung cancer. 23111416

2013

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Further investigations showed that the PI3K/Akt signalling pathway and COX-2 are involved in endothelial tube formation under the stimulation of lung cancer cells. 28173828

2017

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Long non-coding RNA OECC promotes cell proliferation and metastasis through the PI3K/Akt/mTOR signaling pathway in human lung cancer. 31452780

2019

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations. 26013318

2015

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 AlteredExpression BEFREE IFN-γ-mediated inhibition of lung cancer correlates with PD-L1 expression and is regulated by PI3K-AKT signaling. 29516506

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Effect of miR-21 on Apoptosis in Lung Cancer Cell Through Inhibiting the PI3K/ Akt/NF-κB Signaling Pathway in Vitro and in Vivo. 29669316

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway regulates a diverse set of cellular functions relevant to the growth and progression of lung cancer, including proliferation, survival, migration, and invasion. 28125432

2017

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Together with the in vivo data demonstrating a strong tumor-promoting activity of PRR14 and the mutants, our work uncovered this proline-rich protein as a novel activator of the PI3K pathway that promoted tumorigenesis in lung cancer. 27041574

2016

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Additionally, Aclidinium Bromide suppressed the PI3K/AKT signaling pathway in lung cancer A549 cells. 31128006

2019

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Furthermore, cotreatment with sesamin and CAY10404 markedly reduced the levels of phosphorylated protein kinase B (pAkt) and phosoinositide 3 kinase (PI3K) in three lung cancer cell lines. 30365050

2019

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Our findings also suggested that the inhibitory effects of AC-93253 iodide on lung cancer progression may be attributable to its ability to modulate multiple proteins, including Src, PI3K, JNK, Paxillin, p130cas, MEK, ERK, and EGFR. 29132432

2017

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE The PI3K/Akt/mTOR axis in lung cancer is frequently activated and implicated in tumorigenesis. 24472538

2014

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer. 29864375

2018

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE This finding set the stage for further testing of FLJ10540 as a new therapeutic target for treating lung cancer and may contribute to the development of new therapeutic strategies that are able to block the PI3K/AKT pathway in lung cancer cells. 19337377

2009

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 Biomarker BEFREE Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and self-renewal of lung cancer stem cells. 25738369

2015