×
Entrez Id:
7704
Gene Symbol:
ZBTB16
ZBTB16
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
The downstream effectors, FOXO3a, PLZF and VEGF, are reported to be involved in angiogenesis, lymph node metastasis and poor survival in PC .
31087222
2020
×
Entrez Id:
3691
Gene Symbol:
ITGB4
ITGB4
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
ITGB4 and p-ITGB4 -Y1510 were highly expressed in pancreatic cancer (n = 176) compared with normal pancreatic tissue (n = 171).
31242404
2020
×
Entrez Id:
5310
Gene Symbol:
PKD1
PKD1
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
PKD1 expression in PanCa was investigated by using immunohistochemistry.
31819177
2020
×
Entrez Id:
2185
Gene Symbol:
PTK2B
PTK2B
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Our study demonstrates the critical role of TYRO3 in PC progression through Akt and ERK activation and suggests TYRO3 as a novel promising target for therapeutic strategies against PC .
31765735
2020
×
Entrez Id:
7041
Gene Symbol:
TGFB1I1
TGFB1I1
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
Statistical analysis revealed that Hic-5 expression was higher among the pancreatic cancer group than among the normal group and was negatively correlated with postoperative survival time among patients with pancreatic cancer .
31683179
2020
×
Entrez Id:
100885775
Gene Symbol:
BANCR
BANCR
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
LncRNA BANCR Promotes Pancreatic Cancer Tumorigenesis via Modulating MiR-195-5p/Wnt/β-Catenin Signaling Pathway.
31769353
2020
×
Entrez Id:
22868
Gene Symbol:
FASTKD2
FASTKD2
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
FASTKD2 might be a potential target for pancreatic cancer therapy.
31692063
2020
×
Entrez Id:
1113
Gene Symbol:
CHGA
CHGA
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
High CgA levels may predict poor prognosis in patients with pancreatic cancer , especially during metastatic stages.
31091213
2020
×
Entrez Id:
693192
Gene Symbol:
MIR607
MIR607
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Besides, LINC01559 was revealed to be mainly in the cytoplasm of PC cells and therefore served as a ceRNA of Yes-associated protein (YAP) in PC cells via sponging miR-607 .
31608998
2020
×
Entrez Id:
407020
Gene Symbol:
MIR28
MIR28
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
What is more, SEMA7A was found to be a target gene for miR-28 -5p and was upregulated in PC .
31732974
2020
×
Entrez Id:
58516
Gene Symbol:
SINHCAF
SINHCAF
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
FAM60A has been found showing high levels in some cancer cells, including lung cancer (A549), and pancreatic cancer (Capan-2 ) cell lines.
31727367
2020
×
Entrez Id:
574442
Gene Symbol:
MIR489
MIR489
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
Compared with normal adjacent tissues and normal pancreatic cells, the expression of miR-489 was markedly down-regulated in PC tissues and cells.
31646811
2020
×
Entrez Id:
550643
Gene Symbol:
NBDY
NBDY
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Importantly, KRAS was proved to mediate LINC01420 -facilitated PC cell proliferation.
31562613
2020
×
Entrez Id:
22861
Gene Symbol:
NLRP1
NLRP1
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC /NACRT) can be performed in patients with pancreatic cancer to improve survival.
31060118
2020
×
Entrez Id:
2746
Gene Symbol:
GLUD1
GLUD1
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
Clinically, XLOC_006390 was positively correlated with the mRNA level of GDH1 , and c-Myc positively regulated GDH1 gene expression, which was tightly associated with PC patient prognosis.
31734356
2020
C16orf74
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Thus, this study demonstrates that dimerized C16orf74 , present in the cell membrane, is involved in pancreatic cancer invasion and proliferation.
31597713
2020
×
Entrez Id:
25907
Gene Symbol:
TMEM158
TMEM158
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
Collectively, TMEM158 was upregulated in PC and promoted PC cell proliferation, migration, and invasion through the activation of TGFβ1 and PI3K/AKT signaling pathways, highlighting its potential as a tumor promoter and a therapeutic target for PC .
31531884
2020
×
Entrez Id:
5313
Gene Symbol:
PKLR
PKLR
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
Furthermore, HK1, PKLR , and LDHA expression correlated positively with PC progression.
31689601
2020
×
Entrez Id:
7832
Gene Symbol:
BTG2
BTG2
Malignant neoplasm of pancreas
0.010
AlteredExpression
BEFREE
Our results revealed that miR-27a was highly expressed, while BTG2 was poorly expressed in both PC tissues and cell lines. miR-27a targeted BTG2.
31724333
2020
×
Entrez Id:
5927
Gene Symbol:
KDM5A
KDM5A
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
A novel KDM5A /MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
31641207
2020
LOXL1-AS1
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Therefore, the function of LOXL1-AS1 was further explored in PC , presenting that LOXL1-AS1 suppression inhibited cell proliferation and migration.
31732974
2020
×
Entrez Id:
64754
Gene Symbol:
SMYD3
SMYD3
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
To explore the role of SMYD3 in the pancreatic cancer .
31441002
2020
×
Entrez Id:
7504
Gene Symbol:
XK
XK
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC /NACRT) can be performed in patients with pancreatic cancer to improve survival.
31060118
2020
×
Entrez Id:
259266
Gene Symbol:
ASPM
ASPM
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Elucidating the roles of ASPM isoforms reveals a novel prognostic marker for pancreatic cancer .
31595972
2020
×
Entrez Id:
10892
Gene Symbol:
MALT1
MALT1
Malignant neoplasm of pancreas
0.010
Biomarker
BEFREE
Therefore, we studied the impact of pharmacological MALT1 inhibition in pancreatic cancer and showed promising effects on tumor progression.
31291468
2020