Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 Biomarker PSYGENET FGF2, the most widely characterized family member, is down-regulated in the depressed brain and plays a protective role in rodent models of affective disorders. 26351673

2015
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0019284
Disease: Diaphragmatic Hernia
Diaphragmatic Hernia 		0.300 Biomarker CTD_human Administration of antenatal glucocorticoids upregulates peptide growth factor gene expression in nitrofen-induced congenital diaphragmatic hernia in rats. 10646786

2000
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.340 Therapeutic CTD_human Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. 17093919

2007
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancer. 12644816

2003
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.340 Biomarker CTD_human An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancer. 12644816

2003
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0235874
Disease: Disease Exacerbation
Disease Exacerbation 		0.300 Biomarker CTD_human An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancer. 12644816

2003
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0014549
Disease: Tonic-Clonic Epilepsy
Tonic-Clonic Epilepsy 		0.300 Biomarker CTD_human At 4 h following pilocarpine-induced seizures, expression of NGF, BDNF, HB-EGF, and FGF-2 increased only in the mice manifesting tonic-clonic convulsions and not in mice without seizures. 16023256

2005
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0751955
Disease: Brain Infarction
Brain Infarction 		0.310 Therapeutic CTD_human Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity. 17524524

2007
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0393953
Disease: Anterior Cerebral Circulation Infarction
Anterior Cerebral Circulation Infarction 		0.300 Therapeutic CTD_human Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity. 17524524

2007
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0751952
Disease: Anterior Circulation Brain Infarction
Anterior Circulation Brain Infarction 		0.300 Therapeutic CTD_human Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity. 17524524

2007
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0751953
Disease: Brain Infarction, Posterior Circulation
Brain Infarction, Posterior Circulation 		0.300 Therapeutic CTD_human Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity. 17524524

2007
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0751954
Disease: Venous Infarction, Brain
Venous Infarction, Brain 		0.300 Therapeutic CTD_human Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity. 17524524

2007
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.300 Biomarker CTD_human Common variation in GPC5 is associated with acquired nephrotic syndrome. 21441931

2011
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C1383860
Disease: Cardiac Hypertrophy
Cardiac Hypertrophy 		0.300 Biomarker CTD_human Consequently, FGF2 plays a major role in cardiac hypertrophy. 10491406

1999
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.300 Biomarker CTD_human Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion. 16526316

2006
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization 		0.380 Biomarker CTD_human Experiments examining thalidomide's enantiomers reveal-that the S(-)-enantiomer has the strongest antiangiogenic activity in VEGF-induced and bFGF-induced corneal neovascularization. 9301478

1997
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker CTD_human Expression of basic fibroblast growth factor in rat liver fibrosis and hepatic stellate cells. 16116963

2005
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Fibroblast growth factor-2 mediates pressure-induced hypertrophic response. 10491406

1999
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.320 Therapeutic CTD_human Gene therapy in cardiac surgery: intramyocardial injection of naked plasmid DNA for chronic myocardial ischemia. 14583313

2003
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker PSYGENET Given the neuroprotective activity of FGF-2, the data presented here might be relevant to the deficit in cognition and other symptoms that appear in schizophrenia. 11264663

2001
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.300 Therapeutic CTD_human Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide. 10203697

1998
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0017639
Disease: Gliosis
Gliosis 		0.300 Therapeutic CTD_human Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. 21087489

2010
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0011573
Disease: Endogenous depression
Endogenous depression 		0.300 Biomarker CTD_human Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. 16861106

2006
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0025193
Disease: Melancholia
Melancholia 		0.300 Biomarker CTD_human Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. 16861106

2006
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0086133
Disease: Depressive Syndrome
Depressive Syndrome 		0.300 Biomarker CTD_human Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. 16861106

2006