×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF as a target for cancer therapy.
21426297 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
22281684 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
22180495 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.
21163703 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
23845441 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
24163374 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
The road to resistance: EGFR mutation and cetuximab.
22310681 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
23325582 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.
20413299 2010
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF V600E is a determinant of sensitivity to proteasome inhibitors.
24107445 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer.
25989278 2015
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).
18186519 2008
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
22608338 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.
20350999 2010
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.
24594804 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?
21129611 2010
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis.
21716161 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.
19363522 2009
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
22448344 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.
21343559 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Clinical biomarkers in oncology: focus on colorectal cancer.
19537845 2009
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
23549875 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.
19001320 2008