Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 AlteredExpression BEFREE MDR1 gene expression may, in part, explain the responsiveness to chemotherapy in these distinct subtypes of acute leukemia. 8477061

1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 Biomarker BEFREE Thirteen out of 16 (81%) MDR-1 positive patients developed acute leukemia versus two of ten (20%) MDR-1 negative patients (p = 0.025). 8100604

1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 AlteredExpression BEFREE Investigations of mdr1 regulation in normal hematopoietic elements has shown a pattern which corresponds to its regulation in acute leukemia, explaining the linkage of mdr1 to specific cellular phenotypes. 1283551

1992
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 AlteredExpression BEFREE Quantitative determination of mdr1 gene expression in leukaemic cells from patients with acute leukaemia. 1380280

1992
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 AlteredExpression BEFREE These data suggest that mdr1 expression contributes to chemoresistance in acute leukemia. 1859877

1991
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 AlteredExpression BEFREE Thus, P-glycoprotein expression and mdr1 gene amplification occurred infrequently not only in leukemia cells at the initial presentation but also in those at the relapsed cases and may not be a major cause of refractoriness to antileukemia drugs in adult acute leukemia. 2564311

1989