Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE In C57Bl/6 mice harboring lung metastases of melanoma, the administration of three sequential i.v. injections of 10(5) endothelial cells expressing a human interleukin 2 transgene abrogated the tumor metastases and prolonged survival of the animals. 11593332

2001
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Human interleukin 2 (IL-2; Proleukin) is an approved therapeutic for advanced-stage metastatic cancer; however, its use is restricted because of severe systemic toxicity. 11062441

2000
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response. 9742914

1998
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Ad.IL2 before B16 cell challenge and Ad.beta gal-treated mice had similar numbers of metastases as controls (P > 0.1). 9813669

1998
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Successful immunotherapy of established B16 melanoma metastases in C57BL/6 mice can be achieved by antibody-targeted interleukin-2 administration. 8823372

1996
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo. 8940638

1996
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Enhanced efficacy of combination of IL-2 gene and IL-6 gene-transfected tumor cells in the treatment of established metastatic tumors. 9156803

1996
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE T-cell receptor beta variable region diversity in melanoma metastases after interleukin 2-based immunotherapy. 9816229

1996
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Generation of interleukin-2-secreting melanoma cell populations from resected metastatic tumors. 8054375

1994
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 GeneticVariation BEFREE Thus, signs of active responsiveness in terms of lymphokine gene mRNA are seldom detectable in melanoma metastases. 8181865

1994
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker BEFREE Further characterization of these T cells may contribute to a better understanding of in vivo effects of IL-2 on renal-cell carcinoma metastases. 8325704

1993