|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
Biomarker |
BEFREE |
A significant association between HLA-DRB1*04 (OR = 3.86; pcor = 0.0001) and DRB1*14 (OR = 8.4; pcor = 0.0001) and pemphigus vulgaris was found.
|
14760938 |
2003 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
Biomarker |
BEFREE |
We have analysed the characteristics of the 'pockets' of the susceptibility-associated molecules to PV and PF and we showed that (i) in PV, two kinds of Dsg3 derived peptides may be presented by HLA-DR according to HLA polymorphism (DRB1*0402 or DRB1*14/0406), (ii) the same Dsg1 peptides may be presented by DRB1*0102, DQB1*0404 or DRB1*14 in PF, (iii) the DRB1*14/0406 PV-related molecules may be able to present Dsg1 and Dsg3 peptides thereby providing an explanation for the cases of PV with combined responses to Dsg1 and to Dsg3 which are typified by a muco-cutaneous clinical phenotype.
|
10936030 |
2000 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
Biomarker |
BEFREE |
Therefore, at least in Italian patients, pemphigus vulgaris and pemphigus foliaceus share DRB1*1401 and DQB1*0503, as susceptible human leukocyte antigen alleles, whereas DRB1*0402 is only found associated with pemphigus vulgaris.
|
10417627 |
1999 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation |
BEFREE |
All DRB1*04 and DRB1*14 alleles carried by PV patients with different ethnic backgrounds reported to date, including DRB1*0402, which confers strong susceptibility to PV among Jewish populations, have amino acid residues Phe26, Leu67 or Ile67, and Val86, as well as hydrophilic amino acid residues at positions 70 and 71 of the DRB1 beta chain.
|
9714477 |
1998 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation |
BEFREE |
Taking together these data, we can conclude that, in the Spanish population, PV is preferentially and strongly associated with HLA-DRB1*0402, whereas DRB1*13 seems to confer a protective effect in our population.
|
9802608 |
1998 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation |
BEFREE |
Thus our findings, together with previous HLA studies on pemphigus vulgaris patients of different ethnic groups, suggest that HLA-DRB1*04 and DRB1*14 alleles are commonly associated with pemphigus vulgaris across racial barriers.
|
9347787 |
1997 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation |
BEFREE |
The strength of the allele associations to PV is in agreement with the view that the main PV susceptibility genes are the DRB1*0402 and DQB1*0503 alleles.
|
9008308 |
1996 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation |
BEFREE |
We compared high resolution MHC class II alleles and haplotype frequencies (HLA-DRB, DQA1 and DQB1) in 37 patients with PV to 89 haplotypes of normal relatives from New Delhi and Ahmedabad.
|
9008309 |
1996 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
Biomarker |
BEFREE |
Susceptibility to pemphigus vulgaris (PV), an autoimmune disease of the skin, is linked to a rare subtype of HLA-DR4 (DRB1*0402, 1 of 22 known DR4 subtypes).
|
8524878 |
1995 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
Biomarker |
BEFREE |
There was a significant association of either DQB1*0503 or DRB1*1405 with PV, and a negative association of either DQA1*0103 or DQB1*0601 with PV was found.
|
7871526 |
1994 |
|
HLA-DRB1
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation |
BEFREE |
Since 86% (19 of 22) of DRw6+ patients contain the DQB1.3 allele (vs. 3% of controls), whereas 64% (14 of 22) contain the DRB1 allele 6B (vs. 6% of the controls), we conclude that most of the DRw6 susceptibility to PV can be accounted for by the DQ beta chain.
|
2503828 |
1989 |