Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker BEFREE Surgical resection specimens of patients with laryngeal SCC were stained for PTEN protein using a primary rabbit polyclonal anti-PTEN antibody. 17475427

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression BEFREE Reduced PTEN expression progressively increased along the continuum from normal epithelium to squamous cell carcinoma (P < 0.01). 16482604

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 GeneticVariation BEFREE The frequency of cancer-related gene methylation in SCCs was: CDH1 (95%), p16 (20%), p14 (15%), DAPK1 (15%), MGMT (15%), RB1 (5%), RASSF1 (5%), p15 (0%), PTEN (0%), PRDM2 (0%) and p53 (0%). 17034532

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 PosttranslationalModification BEFREE PTEN promoter methylation was detected in 40% (4/10) of CIN-H and 58% (36/62) of SCC specimens. 15196854

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression BEFREE Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system. 12224530

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 GeneticVariation BEFREE Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. 11801303

2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker BEFREE We have assessed the status of PTEN and associated pathways in cell lines derived from 19 squamous cell carcinomas of the head and neck. 11401316

2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker BEFREE Immunohistochemical study showed that the PTEN/MMAC1 protein was localized dominantly in the cytoplasm and strongly stained in all 42 surgically resected esophageal squamous cell carcinomas and normal esophageal epithelium. 10995879

2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 GeneticVariation BEFREE Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas. 10748870

1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression BEFREE Our results indicate that inactivation of PTEN does not play an important role in the carcinogenesis of SCC. 10215192

1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 GeneticVariation BEFREE The purpose of this study was to investigate the presence and importance of PTEN/MMAC1 mutations in squamous cell carcinomas. 9778300

1998