Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 AlteredExpression BEFREE Combining MYC, BCL2 and TP53 gene and protein expression alterations improves risk stratification in diffuse large B-cell lymphoma. 25284491

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma. 26324762

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE TP53 dysfunction in diffuse large B-cell lymphoma. 26315382

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE Mutations or copy number losses of CD58 and TP53 genes in diffuse large B cell lymphoma are independent unfavorable prognostic factors. 27825110

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE Loss-of-function mutations and copy number alterations in the tumor suppressors TP53 (diffuse large B-cell and follicular lymphoma), CDKN2A (diffuse large B-cell and marginal zone lymphoma), PTEN (diffuse large B-cell lymphoma), ATM (diffuse large B-cell lymphoma), and NF1 (diffuse large B-cell lymphoma), and gain-of-function mutations in the oncogenes HRAS (follicular lymphoma) and NRAS (diffuse large B-cell lymphoma) were also observed. 27102345

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE Of those with the morphology of diffuse large B-cell lymphoma, the EBV-negative cases were more frequently TP53-mutated (P<0.001), p53 positive by immunohistochemistry (P<0.001), CD30 negative (P<0.01), and of germinal center immunophenotype (P=0.01) compared with EBV-positive cases. 27443517

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE Deletion and mutation, usually associated, of ATM or TP53 are frequent in Diffuse Large B-Cell Lymphoma and Mantle Cell Lymphoma. 28284458

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 AlteredExpression BEFREE We studied P53 expression in 201 patients with untreated de novo diffuse large B-cell lymphoma. 27739436

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE The prognostic role of Bcl-2, Ki67, c-MYC and p53 in diffuse large B-cell lymphoma. 29250662

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 GeneticVariation BEFREE Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. 28484276

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE The results also provide insights into the regulation and function of p50 in diffuse large B-cell lymphoma and its cross talk with the p53 pathway with important therapeutic implications. 28281555

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 Biomarker BEFREE Integration of bioinformatics and experiments to identify TP53 as a potential target in Emodin inhibiting diffuse large B cell lymphoma. 30096626

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 AlteredExpression BEFREE Increased interleukin-17A levels promote rituximab resistance by suppressing p53 expression and predict an unfavorable prognosis in patients with diffuse large B cell lymphoma. 29512700

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 GeneticVariation BEFREE Progressive diffuse large B-cell lymphoma with TP53 gene mutation treated with chidamide-based chemotherapy. 30606076

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 PosttranslationalModification BEFREE Instances of TP53 promoter methylation were observed only in a few samples of diffuse large B-cell lymphoma tissue. 30871527

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 AlteredExpression BEFREE CD5 expression correlates with inferior survival and enhances the negative effect of p53 overexpression in diffuse large B-cell lymphoma. 31359442

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.300 AlteredExpression BEFREE Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. 31187468

2019