Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3164
Gene Symbol: NR4A1
NR4A1
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.350 AlteredExpression BEFREE 1,1-Bis(3'-indolyl)-1-(p-anisyl)methane (DIM-C-pPhOCH3) activates the orphan receptor nerve growth factor-induced Balpha (Nur77) in cancer cells, and in this study, DIM-C-pPhOCH3 decreased Panc1 pancreatic cancer cell survival and arrested cells in G0-G1. 19584258

2009

Entrez Id: 887
Gene Symbol: CCKBR
CCKBR
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.100 GeneticVariation BEFREE 10, 689-694) have identified a splice variant of CCK2R, called CCK2i4svR, that is expressed in human colorectal and pancreatic cancers but not by cells of the adjacent nonmalignant tissue. 15292208

2004

Entrez Id: 10333
Gene Symbol: TLR6
TLR6
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE 18 SNPs in 14 candidate genes (CSF2, DENND1B, DPP10, FLG, IL13, IL13RA2, LRP1B, NOD1, NPSR1, ORMDL3, RORA, STAT4, TLR6, TRA) were significantly associated with pancreas cancer risk. 25945796

2015

Entrez Id: 6955
Gene Symbol: TRA
TRA
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.040 GeneticVariation BEFREE 18 SNPs in 14 candidate genes (CSF2, DENND1B, DPP10, FLG, IL13, IL13RA2, LRP1B, NOD1, NPSR1, ORMDL3, RORA, STAT4, TLR6, TRA) were significantly associated with pancreas cancer risk. 25945796

2015

Entrez Id: 573
Gene Symbol: BAG1
BAG1
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.020 Biomarker BEFREE 4-HAP also reduced liver metastases in human pancreatic cancer-bearing nude mice. 31358530

2019

Entrez Id: 6294
Gene Symbol: SAFB
SAFB
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 Biomarker BEFREE 4-HAP also reduced liver metastases in human pancreatic cancer-bearing nude mice. 31358530

2019

Entrez Id: 5915
Gene Symbol: RARB
RARB
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 Biomarker BEFREE 4-HAP also reduced liver metastases in human pancreatic cancer-bearing nude mice. 31358530

2019

Entrez Id: 10313
Gene Symbol: RTN3
RTN3
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 Biomarker BEFREE 4-HAP also reduced liver metastases in human pancreatic cancer-bearing nude mice. 31358530

2019

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.090 GeneticVariation BEFREE 5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer. 15941958

2005

Entrez Id: 6581
Gene Symbol: SLC22A3
SLC22A3
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.040 Biomarker BEFREE 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin. 29258566

2017

Entrez Id: 3702
Gene Symbol: ITK
ITK
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.020 Biomarker BEFREE 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin. 29258566

2017

Entrez Id: 2022
Gene Symbol: ENG
ENG
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.020 Biomarker BEFREE 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin. 29258566

2017

Entrez Id: 23650
Gene Symbol: TRIM29
TRIM29
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.030 Biomarker BEFREE : TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. 30389700

2018

Entrez Id: 50852
Gene Symbol: TRAT1
TRAT1
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.010 Biomarker BEFREE : TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. 30389700

2018

Entrez Id: 6382
Gene Symbol: SDC1
SDC1
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.040 AlteredExpression BEFREE Pancreatic cancer cell lines expressed syndecan-1 mRNA and protein at variable levels. 10962434

2000

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.600 GeneticVariation BEFREE Pancreatic cancer exhibits a high frequency of K-ras gene mutations; however, it is not known whether DOC-2 expression is altered in these tumors. 11406647

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.800 AlteredExpression BEFREE Pancreatic cancer is particularly resistant to apoptosis by antineoplastic agents, which is partly attributable to the lack of functional p53. 11585734

2001

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Pancreatic cancer cells are susceptible to antiproliferative effects of cytokines such as tumor necrosis factor-alpha (TNF-alpha). 11854621

2002

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. 12167581

2002

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. 12167581

2002

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.600 GeneticVariation BEFREE Pancreatic cancer is seen in some breast cancer families with BRCA1 and BRCA2 mutations. 12670518

2003

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.800 GeneticVariation BEFREE Pancreatic cancer is seen in some breast cancer families with BRCA1 and BRCA2 mutations. 12670518

2003

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.600 Biomarker BEFREE Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras. 16166322

2005

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.600 GeneticVariation BEFREE Pancreatic cancer is usually initiated by mutation of KRAS and aberrant expression of SHH. 16367914

2006

Entrez Id: 6469
Gene Symbol: SHH
SHH
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.060 AlteredExpression BEFREE Pancreatic cancer is usually initiated by mutation of KRAS and aberrant expression of SHH. 16367914

2006