|
rs12454712
|
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders.
|
20122683 |
2010 |
|
rs12454712
|
|
Generalized Anxiety Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders.
|
20122683 |
2010 |
|
rs12457893
|
|
Kidney Failure, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two of these were in the BCL2 gene and both were associated with a decreased risk of acute kidney injury (rs8094315: odds ratio 0.61, p = .0002; rs12457893: odds ratio 0.67, p = .0002, both for combined data).
|
22710204 |
2012 |
|
rs1310296388
|
|
Congenital Nonbullous Ichthyosiform Erythroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because of evidences that transglutaminase enzymes are involved in programmed cell death, we investigated morphological and biochemical apoptotic parameters in cultured skin fibroblasts from a patient with a severe LI and homozygous for the TGM1 R142H mutation.
|
19278426 |
2009 |
|
rs1473418
|
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, three SNPs, rs1473418 in BCL2, rs1950252 in BCL2L2 and rs511044 in CASP1, are being implicated for the first time in oral cancer.
|
26403071 |
2015 |
|
rs1473418
|
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, three SNPs, rs1473418 in BCL2, rs1950252 in BCL2L2 and rs511044 in CASP1, are being implicated for the first time in oral cancer.
|
26403071 |
2015 |
|
rs1564483
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multiple functional BCL-2 genetic polymorphisms, such as rs2279115, rs1801018 and rs1564483, have been identified previously and might be involved in cancer development through deregulating BCL-2 expression.
|
26132559 |
2015 |
|
rs1564483
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multiple functional BCL-2 genetic polymorphisms, such as rs2279115, rs1801018 and rs1564483, have been identified previously and might be involved in cancer development through deregulating BCL-2 expression.
|
26132559 |
2015 |
|
rs1564483
|
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, advanced NSCLC males carrying BCL2 rs1564483 GA+AA genotypes had significantly longer median survival time (Long-rank P = 0.036) and decreased death risk (adjusted HR = 0.69, P = 0.027) than patients with rs1564483GG genotype.
|
23977251 |
2013 |
|
rs1564483
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
For BCL2, minor allele carriers of rs1564483 were more likely to have hormone receptor-positive tumours than the major homozygotes.
|
22037783 |
2012 |
|
rs17757541
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, this study demonstrated that Fas rs2234767 G/A and Bcl2 rs17757541 T/C polymorphisms might be associated with an increased risk of RA.
|
26905515 |
2016 |
|
rs17757541
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
B-cell lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of coronary artery disease in a Chinese population.
|
26823859 |
2015 |
|
rs17757541
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
B-cell lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of coronary artery disease in a Chinese population.
|
26823859 |
2015 |
|
rs17757541
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, the results indicated that there is a close correlation between the BCL2 rs17757541</span> C>G polymorphism and CAD, which suggests that this SNP site should be further studied as a potential biomarker for CAD.
|
26823859 |
2015 |
|
rs17757541
|
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
B-cell Lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population.
|
23991993 |
2013 |
|
rs17757541
|
|
Adenocarcinoma Of Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).
|
21472143 |
2011 |
|
rs17759659
|
|
Autoimmune thyroiditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the blood serum cytokines' rate and lymphocytes' apoptosis with polymorphic variants of the BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1÷FAS (rs2234767) genes in patients with nodular goiters in autoimmune thyroiditis and thyroid adenoma.
|
29250672 |
2017 |
|
rs17759659
|
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the blood serum cytokines' rate and lymphocytes' apoptosis with polymorphic variants of the BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1÷FAS (rs2234767) genes in patients with nodular goiters in autoimmune thyroiditis and thyroid adenoma.
|
29250672 |
2017 |
|
rs17759659
|
|
Thyroid Gland Follicular Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the blood serum cytokines' rate and lymphocytes' apoptosis with polymorphic variants of the BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1÷FAS (rs2234767) genes in patients with nodular goiters in autoimmune thyroiditis and thyroid adenoma.
|
29250672 |
2017 |
|
rs17759659
|
|
Nodular Goiter
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the blood serum cytokines' rate and lymphocytes' apoptosis with polymorphic variants of the BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1÷FAS (rs2234767) genes in patients with nodular goiters in autoimmune thyroiditis and thyroid adenoma.
|
29250672 |
2017 |
|
rs1800477
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Bcl-2 rs1800477A/G polymorphism may be related to the occurrence of CRC, and GG genotype could be a risk factor of poor prognosis in CRC.
|
28106544 |
2017 |
|
rs1800477
|
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GG genotype of rs1800477A/G was associated with lymph node metastasis and Dukes' staging of CRC (both P < 0.05).
|
28106544 |
2017 |
|
rs1800477
|
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms of - 938C/A and Thr43Ala in the BCL-2 gene and G - 248A in the BAX gene are associated with the risk of developing non-Hodgkin lymphoma (NHL).
|
24024471 |
2014 |
|
rs1800477
|
|
B-Cell Lymphomas
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purpose of the present study was to investigate the polymorphisms of -938C/A, Thr43Ala in anti-apoptotic B-cell lymphoma 2 gene (BCL2) and -248G/A in pro-apoptotic B-cell lymphoma 2-associated X protein gene (BAX) and to explore their role in influencing the susceptibility for development of esophageal cancer.
|
22187149 |
2012 |
|
rs1800477
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Quantification of HCV-RNA by real-time PCR was performed for every patient, and gene polymorphism of BCL-2 (ala 43 Thr) was performed for all patients and controls.
|
21159314 |
2011 |