rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
9 of the remaining 37 were associated with breast cancer risk in young women with a p-value <0.05: rs10510102, rs1219648, rs13387042, rs1876206, rs2936870, rs2981579, rs3734805, rs3803662 and rs4973768.
|
31125336 |
2019 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
rs4973768
|
|
Breast Carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The Na<sup>+</sup>-HCO<sub>3</sub><sup>-</sup> cotransporter NBCn1 (SLC4A7) is up-regulated in breast cancer, important for tumor growth, and a single nucleotide polymorphism (SNP), rs4973768, in its 3' untranslated region (3'UTR) correlates with increased breast cancer risk.
|
27609814 |
2016 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
rs4973768
|
|
Breast Carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
rs4973768
|
|
Breast Carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings emphasized the proof of principle that multiple interactions of genetic variants, including rs3757318, rs2046210, and rs4973768 may play important roles in the susceptibility of BC though the biological mechanisms underlying the observed associations need to be elucidated.
|
24265035 |
2013 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In summary, our results showed that the SLC4A7 variant, rs4973768, is associated with risk of BC although the underlying biologic mechanism warrants further studies.
|
23117855 |
2012 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients.
|
22532573 |
2012 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Polymorphic variants of 2q35-rs13387042, 3p24-rs4973768, 17q23-rs650490 and FGFR2-rs2981578 were analyzed to test for their association with breast cancer susceptibility.
|
22287734 |
2012 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
rs4973768
|
|
Breast Carcinoma
|
C |
0.800 |
GeneticVariation
|
GWASCAT |
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
|
21263130 |
2011 |
rs4973768
|
|
Breast Carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies five new breast cancer susceptibility loci.
|
20453838 |
2010 |
rs4973768
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The minor alleles of rs4973768 and rs10941679 were associated with increased breast cancer risk for BRCA2 carriers (per-allele HR = 1.10, 95% CI: 1.03-1.18, P = 0.006 and HR = 1.09, 95% CI: 1.01-1.19, P = 0.03, respectively).
|
21118973 |
2010 |
rs4973768
|
|
Breast Carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
|
19330027 |
2009 |