rs11506105
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, rs11506105 was significantly associated with an increased risk of glioma in both Asians and Caucasians, and rs11979158 decreased the risk of glioma in Caucasians.
|
29156842 |
2017 |
rs12718945
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians.
|
29156842 |
2017 |
rs17172432
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians.
|
29156842 |
2017 |
rs3752651
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians.
|
29156842 |
2017 |
rs397517132
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrated that overexpression of PTPN9 reduces EGFR phosphorylation and cooperates with BRAF(V</span>600E</span>) in</span>hibitor PLX4720 to reduce MAPK and Akt signaling, resulting in decreased glioma cell viability.
|
26023796 |
2015 |
rs4947492
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians.
|
29156842 |
2017 |
rs845552
|
|
Glioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed a significant positive association between rs730437/rs845552 and glioma risk in Asians, and a significant negative association between them in Caucasians.
|
29156842 |
2017 |
rs1468727
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that the CC genotype of rs1468727 was more common in the glioma group than in the control group (p=0.021).
|
25514356 |
2015 |
rs1468727
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We identified two susceptibility tSNPs in the EGFR gene that were potentially associated with an increased risk of glioma (rs730437, p = 0.016; OR: 1.32; 95%CI: 1.05-1.66 and rs1468727, p = 0.008; OR: 1.31; 95%CI: 1.04-1.65).
|
22662167 |
2012 |
rs1468727
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk.
|
23244079 |
2012 |
rs730437
|
|
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results showed a significant positive association between rs730437/rs845552 and glioma risk in Asians, and a significant negative association between them in Caucasians.
|
29156842 |
2017 |
rs730437
|
|
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
These data suggest that five EGFR SNPs (rs11506105, rs3752651, rs1468727, rs845552 and rs730437) correlated with glioma patient prognosis, and should be furthered validated in studies of ethnically diverse patients.
|
27437777 |
2016 |
rs730437
|
|
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
For rs730437, we found both the AA genotype (p=0.011) and A allele frequency (p=0.003; OR=0.703; 95% CI: 0.558-0.886) were significantly lower in the glioma patients than in the control subjects, respectively.
|
25514356 |
2015 |
rs730437
|
|
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We identified two susceptibility tSNPs in the EGFR gene that were potentially associated with an increased risk of glioma (rs730437, p = 0.016; OR: 1.32; 95%CI: 1.05-1.66 and rs1468727, p = 0.008; OR: 1.31; 95%CI: 1.04-1.65).
|
22662167 |
2012 |
rs11979158
|
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
In addition, rs11506105 was significantly associated with an increased risk of glioma in both Asians and Caucasians, and rs11979158 decreased the risk of glioma in Caucasians.
|
29156842 |
2017 |
rs11979158
|
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Additionally, subgroup analysis by stages of glioma found that variation of rs11979158 had stronger relationship with high-grade (OR = 1.32, 95 %CI = 1.19-1.45) than low-grade glioma (OR = 1.12, 95 % CI = 1.03-1.21).
|
26243184 |
2016 |
rs11979158
|
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1).
|
23161787 |
2013 |
rs11979158
|
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR).
|
21825990 |
2011 |
rs11979158
|
|
Glioma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively).
|
21531791 |
2011 |