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rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We previously reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene at positions C677T and A1298C were associated with lower risk of adult acute lymphocytic leukemia (ALL).
|
11986237 |
2002 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results do not support the suggestion that populations carrying different genotypes of the two MTHFR polymorphisms, C677T and A1298C, have a different susceptibility to ALL, at least in the Mediterranean area.
|
15003888 |
2004 |
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rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes may have a role in altering susceptibility to adult acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL).
|
15159311 |
2004 |
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rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have analyzed the MTHFR C677T polymorphism in 52 patients and 88 control individuals, all ethnic Greek residents of northern Greece, and examined the association of this polymorphism with (a) susceptibility to childhood ALL and (b) the distribution of average plasma alanine aminotransferase (ALT) levels, white blood cell counts (WBC), and hemoglobin levels (Hb) during the induction and consolidation phases of treatment.
|
16123993 |
2006 |
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rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings support the proposal that the common genetic C677T polymorphism in the MTHFR contributes to the risk of adult ALL, but not to the childhood ALL susceptibility.
|
17035405 |
2006 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no association between the 677C>T or 1298A>C and risk of ALL in total case-control sample.
|
16182363 |
2006 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2 or *3 and the risk of acute lymphoblastic leukemia (ALL).
|
17023046 |
2006 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the influence of C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms on time to relapse and survival and on methotrexate (MTX) toxicity in 82 ALL adult patients.
|
17512587 |
2007 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant difference was found in the development of adult ALL among those with different MTHFR genotypes of the C677T or A1298C polymorphisms.
|
17970089 |
2007 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a case-control study in 95 north Indian children with acute lymphoblastic leukemia (ALL) and 255 controls, to investigate the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of ALL.
|
20367562 |
2010 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL).
|
20374270 |
2010 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Accumulated evidence has demonstrated that C677T and A1298C polymorphisms of the MTHFR gene are associated with acute lymphoblastic leukemia (ALL) risk, but the results have been inconclusive.
|
21702646 |
2011 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Seventy-two children with ALL and 109 age- and sex-matched healthy children from Western Iran were screened for MTHFR C677T and A1298C variants by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
|
22017305 |
2012 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants have produced contradictory or inconclusive results.
|
22094326 |
2012 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the adult subgroup, there was no significant association between the C677T variant and ALL risk (Dominant model: OR(RE)=0.88, 95% CI: 0.45-1.72, p=0.72).
|
23061880 |
2012 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping of MTHFR polymorphism, C677T particularly, prior to treatment for ALL is likely to be useful with the aim of tailoring MTX therapy and thus reducing the MTX-related toxicities.
|
22528943 |
2012 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL).
|
22943282 |
2012 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians.
|
24377532 |
2013 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two polymorphisms of the gene encoding MTHFR, C677T and A1298C, alter MTHFR enzyme activity and may be associated with ALL relapse.
|
24637499 |
2014 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn.
|
25342508 |
2014 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicated that the MTHFR C677T T allele was a protective biomarker for childhood ALL in Taiwan, and the association was more significant in male patients and in patients 3.5 years of age or older at onset of disease.
|
25793509 |
2015 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL.
|
25115513 |
2015 |
|
rs1217691063
|
|
Adult Acute Lymphocytic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population.
|
26081619 |
2015 |