|
rs1801133
|
|
Homocysteine measurement
|
A |
0.800 |
GeneticVariation
|
GWASDB |
Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
|
20031578 |
2009 |
|
rs1801133
|
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.
|
23696881 |
2013 |
|
rs1801133
|
|
Homocysteine measurement
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
|
20031578 |
2009 |
|
rs1801133
|
|
Homocysteine measurement
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
|
23824729 |
2013 |
|
rs1801133
|
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.
|
23696881 |
2013 |
|
rs1801133
|
|
Homocysteine measurement
|
A |
0.800 |
GeneticVariation
|
GWASDB |
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
|
23824729 |
2013 |
|
rs1801133
|
|
Homocysteine measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 × 10-17), serum folate (P = 2.82 × 10-11), and plasma total homocysteine (P = 1.26 × 10-19) concentrations.
|
30339177 |
2018 |
|
rs1801133
|
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in schizophrenia.
|
23353103 |
2013 |
|
rs1801133
|
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
However, since our meta-analysis results demonstrated strong support for association of rs1801133 with schizophrenia, further replication studies based on a gene-wide approach need to be considered.
|
20692813 |
2010 |
|
rs1801133
|
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated with increased perseverative errors among patients.
|
21980405 |
2011 |
|
rs1801133
|
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
|
22037552 |
2011 |
|
rs1801133
|
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |
|
rs1801133
|
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
The common mutations found to be associated with schizophrenia and MTHFR are A222V, E429A, and R594Q.
|
28427558 |
2017 |
|
rs1801133
|
|
Schizophrenia
|
|
0.760 |
GeneticVariation
|
BEFREE |
Among the Scandinavian patients the functional MTHFR SNP rs1801133 (C677T) significantly affected age at onset of schizophrenia in a dose-dependent manner (P = 0.0015), with lower age of onset with increasing numbers of the mutant T-allele.
|
19746410 |
2010 |
|
rs1801133
|
|
VITAMIN B12 MEASUREMENT
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|
19303062 |
2009 |
|
rs1801133
|
|
Folic acid measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
We validated that rs1801133 in MTHFR was significantly involved in serum folate (P = 4.21 × 10<sup>-19</sup>).
|
29953918 |
2018 |
|
rs1801133
|
|
Folic acid measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 × 10-17), serum folate (P = 2.82 × 10-11), and plasma total homocysteine (P = 1.26 × 10-19) concentrations.
|
30339177 |
2018 |
|
rs1801133
|
|
RDW - Red blood cell distribution width result
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1801133
|
|
Red cell distribution width determination
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1801133
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the present meta-analysis indicated that MTRR rs1801394, MTR rs1805087, and MTHFR rs1801133 polymorphisms could be used to identify individuals at high risk of developing BC.
|
31549463 |
2020 |
|
rs1801133
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found significant association between the rs1801133 (A222V) genotypes and an increased risk of BC development: C/T (odds ratio [OR] = 1.8; 95 % confidence interval [CI] = 1.1-3.2; P = 0.039), T/T (OR = 2.9; 95 % CI = 1.2-7.2; P = 0.025), and C/T + T/T (OR = 1.9; 95 % CI = 1.1-3.3; P = 0.019).
|
25801246 |
2015 |
|
rs1801133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype analysis also showed that MTHFR CACCAA and AGTCAC haplotypes (rs12121543-rs13306553-rs9651118-rs1801133-rs4846048-rs1801131) had significant reduced risk of breast cancer (adjusted OR = 0.70, 95 % CI 0.58-0.86; adjusted OR = 0.57, 95 % CI 0.40-0.80) compared with CATTAA haplotype.
|
25566964 |
2015 |
|
rs1801133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the independent and the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T (rs1801133) and MTHFR 1298A>C (rs1801131), as well as their interaction with the use of hormone replacement therapy (HRT), to determine their potential contribution to breast cancer risk.
|
21461582 |
2011 |
|
rs1801133
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR gene (rs1801133 and rs1801131) and in the MTRR gene (rs1801394, rs1532268, rs162036, and rs10380) with the risk for colorectal cancer in 666 patients and 1377 controls from the Czech Republic.
|
21211571 |
2011 |
|
rs1801133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evaluation of the two polymorphisms rs1801133 in MTHFR and rs10811661 in CDKN2A/B in breast cancer.
|
30362613 |
2018 |