Analysis for the C1858T polymorphism using the TaqMan assay was performed in 250 subjects with adult-onset autoimmune diabetes, divided into two subgroups with low (<or=32 arbitrary units) or high (>32 arbitrary units) GADA titers and 450 subjects with classic type 2 diabetes (from the Non Insulin Requiring Autoimmune Diabetes [NIRAD] Study cohort of 5,330 subjects with adult-onset diabetes) and in 558 subjects with juvenile-onset type 1 diabetes and 545 normoglycemic subjects.
To evaluate the impact of a functional variation in the PTPN22 gene in type 1 (T1D) and type 2 diabetes</span> (T2D), the PTPN22 C1858T single nucleotide polymorphism (SNP) was studied in the population of Estonian origin, including 170 T1D patients, 244 T2D patients and 230 controls.
We found that the T allele of rs2476601 and the A allele of rs33996649within <i>PTPN22</i> gene, interaction between rs2476601 and T2DM were all associated with increased PTB risk.