|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A case‑control study (90‑100 cases; 90‑100 controls) was performed to evaluate five genetic variants of three genes, including FGFR2 (SNPs: rs1219648, rs2981582), TNRC9 (SNPs: rs8051542, rs3803662) and MAP3K1 (SNP: rs889312) as BC risk factors in Pakistani women.
|
27572905 |
2016 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
A combined analysis of genome-wide association studies in breast cancer.
|
20872241 |
2011 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|
19330030 |
2009 |
|
rs3803662
|
|
Breast Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
At present, no genes have been identified in the linkage disequilibrium block containing rs13387042. rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone.
|
17529974 |
2007 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conclusively, this meta-analysis suggests that TNRC9 rs3803662 polymorphism was significantly correlated with breast cancer risk and the variant T allele of TNRC9 rs3803662 polymorphism is a low-penetrant risk factor for developing breast cancer.
|
20703937 |
2011 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Five common breast cancer susceptibility loci from GWAS are not strongly associated with breast cancer risk among the Han Chinese of the Henan province; only rs3803662 (T</span>OX3/TNRC9) is confirmed to increase the risk of breast cancer.
|
26803517 |
2016 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs3803662
|
|
Breast Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
|
23001122 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
|
23001122 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies five new breast cancer susceptibility loci.
|
20453838 |
2010 |
|
rs3803662
|
|
Breast Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies novel breast cancer susceptibility loci.
|
17529967 |
2007 |
|
rs3803662
|
|
Breast Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of breast cancer in the Japanese population.
|
24143190 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Given that <i>TOX3</i> mRNA is a target of miR-182, and that both the <i>TOX3</i> rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect.
|
30135399 |
2018 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
|
23544012 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In Asian populations, there were significant associations of rs3803662</span> and rs8051542 with breast cancer risk.
|
26239137 |
2015 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, we show that there is little overlap between the breast cancer risk single nucleotide polymorphisms (SNPs) identified so far and the SNPs associated with breast cancer prognosis, with the possible exceptions of LSP1-rs3817198 and TNRC9-rs3803662.
|
25611573 |
2015 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05).
|
22452962 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
No statistically significant association was found between the rs3803662 polymorphism and breast cancer in patients or healthy controls.
|
29683073 |
2018 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
None of the three polymorphisms was significantly associated with breast cancer risk in the whole data set (P = 0.151, 0.644, and 0.737 for rs3803662, rs12443621. and rs8051542, respectively).
|
20213080 |
2010 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Odds ratios for breast cancer were greatest for FGFR2-rs2981582 and TNRC9-rs3803662 and, for these 2 SNPs, were significantly greater for estrogen receptor (ER)-positive than for ER-negative disease, both in our data and in meta-analyses of all published data (pooled per-allele ORs [95% confidence intervals] for ER-positive vs ER-negative disease: 1.30 [1.26-1.33] vs 1.05 [1.01-1.10] for FGFR2; interaction P < .001; and 1.24 [1.21-1.28] vs 1.12 [1.07-1.17] for TNRC9; interaction P < .001).
|
20664043 |
2010 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer.
|
24069142 |
2013 |