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rs13181
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Experimental Organism Basal Cell Carcinoma
|
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0.030 |
GeneticVariation
|
BEFREE |
We have studied the role of two nucleotide substitutions in the XPD gene, one in exon 23 leading to an amino acid substitution (Lys751Gln) and one silent in exon 6 in relation to basal cell carcinoma (BCC).
|
9950243 |
1999 |
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rs13181
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|
Carcinoma, Basal Cell
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|
0.030 |
GeneticVariation
|
BEFREE |
We have studied the role of two nucleotide substitutions in the XPD gene, one in exon 23 leading to an amino acid substitution (Lys751Gln) and one silent in exon 6 in relation to basal cell carcinoma (BCC).
|
9950243 |
1999 |
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rs13181
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|
Xeroderma Pigmentosum, Complementation Group D
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|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that XPD Lys751Gln polymorphism may be an important marker in the prediction of clinical outcome to platinum-based chemotherapy.
|
11751380 |
2001 |
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rs13181
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Experimental Organism Basal Cell Carcinoma
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|
0.030 |
GeneticVariation
|
BEFREE |
We have previously reported that two polymorphisms in the gene, one silent mutation in codon 156 of exon 6 and one giving rise to a Lys-->Gln substitution in codon 751 of exon 23, showed signs of being associated with basal cell carcinoma in a Scandinavian study group of psoriasis patients and non-psoriatics with and without basal cell carcinoma [Dybdahl, Vogel, Frentz, Wallin and Nexø (1999) Cancer Epidemiol.Biomark.Prev., 8, 77-81].
|
11375896 |
2001 |
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rs13181
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|
Carcinoma, Basal Cell
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|
0.030 |
GeneticVariation
|
BEFREE |
We have previously reported that two polymorphisms in the gene, one silent mutation in codon 156 of exon 6 and one giving rise to a Lys-->Gln substitution in codon 751 of exon 23, showed signs of being associated with basal cell carcinoma in a Scandinavian study group of psoriasis patients and non-psoriatics with and without basal cell carcinoma [Dybdahl, Vogel, Frentz, Wallin and Nexø (1999) Cancer Epidemiol.Biomark.Prev., 8, 77-81].
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11375896 |
2001 |
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rs13181
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies suggested that suboptimal DNA repair capacity is associated with cancer risk and that the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementary group D (XPD) gene may influence DNA repair capacity.
|
12399122 |
2002 |
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rs13181
|
|
Primary malignant neoplasm
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|
0.090 |
GeneticVariation
|
BEFREE |
Previous studies suggested that suboptimal DNA repair capacity is associated with cancer risk and that the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementary group D (XPD) gene may influence DNA repair capacity.
|
12399122 |
2002 |
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rs13181
|
|
Squamous cell carcinoma of esophagus
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|
0.040 |
GeneticVariation
|
BEFREE |
Neither Asp312Asn nor Lys751Gln polymorphisms in the XPD gene influenced risk of ESCC in our study.
|
12124811 |
2002 |
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rs13181
|
|
Carcinoma of lung
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|
0.800 |
GeneticVariation
|
BEFREE |
We have described statistically significant interactions between the ERCC2 polymorphisms (Asp312Asn and Lys751Gln) and smoking in lung cancer risk.
|
12692111 |
2003 |
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rs13181
|
|
Xeroderma Pigmentosum, Complementation Group D
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was found between p53 mutations and either XPD Lys751Gln or XRCC1 Arg399Gln.
|
12844488 |
2003 |
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rs13181
|
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Primary malignant neoplasm of lung
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|
0.100 |
GeneticVariation
|
BEFREE |
We have described statistically significant interactions between the ERCC2 polymorphisms (Asp312Asn and Lys751Gln) and smoking in lung cancer risk.
|
12692111 |
2003 |
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rs13181
|
|
Malignant neoplasm of lung
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|
0.100 |
GeneticVariation
|
BEFREE |
We have described statistically significant interactions between the ERCC2 polymorphisms (Asp312Asn and Lys751Gln) and smoking in lung cancer risk.
|
12692111 |
2003 |
|
rs13181
|
|
Carcinoma of lung
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|
0.800 |
GeneticVariation
|
BEFREE |
Among men, carriers of the variant allele of XPD Lys751Gln</span> had a non-significantly increased risk of lung cancer</span> in the youngest age interval (RR=6.38, 95% CI=0.74-54.90).
|
14757194 |
2004 |
|
rs13181
|
|
Carcinoma of lung
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|
0.800 |
GeneticVariation
|
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs13181
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among men, carriers of the variant allele of XPD Lys751Gln</span> had a non-significantly increased risk of lung cancer</span> in the youngest age interval (RR=6.38, 95% CI=0.74-54.90).
|
14757194 |
2004 |
|
rs13181
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs13181
|
|
Xeroderma Pigmentosum, Complementation Group D
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the genetic basis for these findings by analysing the Asp312Asn and Lys751Gln polymorphisms of the XPD (ERCC2) DNA repair gene in the same subjects.
|
14735199 |
2004 |
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rs13181
|
|
Xeroderma Pigmentosum, Complementation Group D
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether the XRCC1 (codon Arg399Gln) and XPD (codon Asp312Asn and codon Lys751Gln) polymorphisms are associated with prostate cancer susceptibility, we genotyped these polymorphisms in a primarily Caucasian sample of 506 sibships (n = 1,117) ascertained through a brother with prostate cancer.
|
14744728 |
2004 |
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rs13181
|
|
Primary malignant neoplasm of lung
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|
0.100 |
GeneticVariation
|
BEFREE |
Among men, carriers of the variant allele of XPD Lys751Gln</span> had a non-significantly increased risk of lung cancer</span> in the youngest age interval (RR=6.38, 95% CI=0.74-54.90).
|
14757194 |
2004 |
|
rs13181
|
|
Breast Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
ERCC2 polymorphisms ERCC2_6540_G>A (Asp(312)Asn) and ERCC2_18880_A>C (Lys(751)Gln) within the coding region of this evolutionarily highly conserved gene have been of functional relevance and therefore are potential candidates to confer breast cancer susceptibility.
|
15598761 |
2004 |
|
rs13181
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met).
|
15333465 |
2004 |
|
rs13181
|
|
Xeroderma Pigmentosum, Complementation Group D
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed polymorphisms in the aryl hydrocarbon receptor (AhR-Arg554Lys), null variants of the glutathione S-transferase superfamily (GSTM1 and GSTT1), x-ray repair cross-complementing 1 and 3, and Xeroderma pigmentosum, group D (XRCC1-Arg399Gln, XRCC3-Thr241Met, XPD-Lys751Gln).
|
15459223 |
2004 |
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rs13181
|
|
Breast Carcinoma
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|
0.100 |
GeneticVariation
|
BEFREE |
In a case-cohort study, we have investigated the occurrence of lung cancer in relation to a high-risk haplotype, previously identified for breast cancer among post-menopausal women, and in relation to the closely linked polymorphisms XPD Asp312Asn and Lys751Gln.
|
14757194 |
2004 |
|
rs13181
|
|
Malignant neoplasm of breast
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|
0.100 |
GeneticVariation
|
BEFREE |
ERCC2 polymorphisms ERCC2_6540_G>A (Asp(312)Asn) and ERCC2_18880_A>C (Lys(751)Gln) within the coding region of this evolutionarily highly conserved gene have been of functional relevance and therefore are potential candidates to confer breast cancer susceptibility.
|
15598761 |
2004 |
|
rs13181
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
When the polymorphisms in XPD Asp312Asn and Lys751Gln were mutually adjusted, XPD Asp312Asn was not associated with increased risk of cancer.
|
14757194 |
2004 |