|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant association was noted in CFH-rs800292, CFH-rs1410996, CFH-rs2274700, and HTRA1-rs11200638 with AMD development (P = 2.36x10(-5), 7.18x10(-5), 7.18x10(-5), 2.70x10(-7), respectively; population attributable risk = 57.3%, 57.8%, 57.8%, and 58.9%, respectively).
|
20132989 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Contrary to previous reports, we show that rs11200638 SNP has no significant impact on HTRA1 promoter activity in three different cell lines, and HTRA1 mRNA expression exhibits no significant change between control and AMD retinas.
|
17884985 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Eight single nucleotide polymorphisms (SNPs) from 6 genes of the HDL metabolism pathway and 2 known AMD-associated SNPs, rs800292 (from complement factor H [CFH]) and rs11200638 (from HtrA serine peptidase 1 [HTRA1]), were genotyped in all study subjects using the TaqMan genotyping technology (Applied Biosystems, Foster City, CA).
|
24393350 |
2014 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.
|
25277308 |
2014 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotypes of 3 polymorphisms in known AMD susceptibility loci (rs1061170 in complement factor H (CFH), rs11200638 in HTRA1 and rs1413711 in VEGF) were determined.
|
24080590 |
2013 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygotes for the risk allele at rs11200638 had a 6.33-fold increased risk of PCV and a 13.77-fold increased risk of wet AMD when compared with homozygotes for the wild-type allele.
|
17692272 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygotes for the T allele of rs10490924 had an odds ratio (OR) of 8.6, with a 95% confidence interval (CI) of 3.5-20.8, and homozygotes for the A allele of rs11200638 had an OR of 10.7, with a 95% CI of 3.2-35.7, for having AMD (p<0.00001).
|
19065273 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, after Bonferroni correction, the genotype and allele distributions of two SNPs in CFH (rs10737680, rs1410996), one SNP (rs10490924) in ARMS2 and one SNP (rs11200638) in HTRA1 differed significantly between the controls and AMD patients.
|
24865190 |
2014 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
HTRA1 rs11200638 G→A polymorphism and LOC387715/ARMS2 rs10490924 G→T polymorphism play important roles in AMD.
|
21031019 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
A |
0.900 |
GeneticVariation
|
GWASDB |
HTRA1 promoter polymorphism in wet age-related macular degeneration.
|
17053108 |
2006 |
|
rs11200638
|
|
Age related macular degeneration
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
HTRA1 promoter polymorphism in wet age-related macular degeneration.
|
17053108 |
2006 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, rs11200638 was significantly associated with soft confluent drusen, which are strongly immunolabeled with HTRA1 antibody in an AMD eye with GA similar to wet AMD.
|
17426452 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this post hoc analysis of cross-sectional data from US participants in the Comparison of AMD Treatments Trials, genotyping was performed in 835 participants with TaqMan assays for the SNPs rs1061170 (Y402H variant in CFH), rs800292 (I62V variant in CFH), rs10490924 (A69S variant in ARMS2), rs11200638 (HTRA1), rs547154 (C2), rs2230199 (R102G variant in C3), rs10468017 (LIPC), and rs4151667 (L9H variant in CFB).
|
29801032 |
2018 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Likewise, HtrA1-rs11200638 was less clearly associated with AMD severity, whereas C2-rs9332739 and CFB-rs641153 showed no relation.
|
19169232 |
2009 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Mapping the genes for age-related macular degeneration (AMD) had not been successful until recent genome-wide association studies revealed Tyr402His in CFH and rs11200638 in HTRA1 as AMD-related genetic variants.
|
18316707 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, recent reports have shown that the rs11200638, a single nucleotide polymorphism (SNP) in the promoter region of the HTRA1 gene, is strongly associated with an increased prevalence of age-related macular degeneration (AMD).
|
19798546 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, the rs11200638-rs2672598 joint genotype AA-CC conferred higher risk to exudative AMD (43.11 folds) than PCV (3.68 folds).
|
27338780 |
2016 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Multiple studies demonstrate a strong association between three variants at chromosome 10q26 - rs10490924, del443ins54, and rs11200638 - near the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) genes with susceptibility to age-related macular degeneration (AMD).
|
20664794 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Purpose.To determine the relationship of six genetic variants (rs10490924, rs3750848, del443ins54, rs3793917, rs11200638, and rs932275) localized to the ARMS2-HTRA1 region of chromosome 10, region q26, as risk factors for age-related macular degeneration (AMD), to define the haplotype structure of these six loci, and to confirm their genetic association with the disease.Methods.
|
19933195 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Rs12153855C and rs9391734A alleles could further increase the susceptibility to AMD in subjects with rs800292, rs11200638 and rs429608 risk alleles.
|
26861912 |
2016 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations with both exudative AMD and PCV were observed in 11 of them and HTRA1 rs11200638</span>, with different genotypic distributions between exudative AMD and PCV (P < 0.001).
|
22491416 |
2012 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations were detected for exudative AMD with SNPs rs10490924:G>T in LOC387715 (A69S), and rs11200638:G>A in the promoter of HTRA1.
|
18682812 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the LOC387715 (rs10490924), HTRA1 (rs11200638), and CFH (rs1061170) genes have been implicated in age-related macular degeneration (AMD).
|
18436811 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
SNP rs10490924 on chromosome 10 in exon 1 of the ARMS2 gene showed a highly significant association with an odds ratio (OR) of 3.2 (95% CI 2.4-4.2) for the risk allele and rs11200638 located in the proximal promoter region of HTRA1 showed a higher significant association with an OR of 3.4 (95% CI 2.5-4.6) with our AMD cases.
|
19259132 |
2009 |