|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects.
|
17260353 |
2007 |
|
rs1045642
|
|
Leukopenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Serum LDH may be a promising predictor of prognosis, and the ABCB1 C3435T polymorphism may be a genetic predictor of the severity of leukocytopenia in patients with CRPC treated with DEC.
|
21706123 |
2012 |
|
rs1045642
|
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicate that the C3435T polymorphism of MDR1 gene may be associated with the incidence of DRE observed in the Polish population.
|
27534401 |
2017 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene.
|
18436433 |
2008 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that C3435T MDR1 polymorphism was not associated with the susceptibility to breast cancer in the population studied.
|
19388849 |
2009 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
With regard to the clinical characteristics of BC, the <i>ABCC2</i> SNPs rs2273697 and rs717620 were found to be significantly associated with age at breast cancer diagnosis and breastfeeding status, while the <i>ABCB1</i> SNP rs1045642 was significantly associated with age at breast cancer diagnosis.
|
31391850 |
2019 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have detected no significant association of C3435T SNP and pediatric CD.
|
27603561 |
2016 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CC genotypes of rs1128503 and rs1045642 in MDR1 gene were more frequent in Crohn's disease (CD) patients who were GC-dependent than in those responsive to GC (odds ratio [OR] 6.583, 95% confidence interval [CI] 1.760-24.628, P = 0.019 and OR 3.873, 95% CI 1.578-9.506, P = 0.009, respectively).
|
25346426 |
2015 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the ABCB1 C3435T polymorphism may be a genetic marker for drug resistance in epilepsy in Caucasian populations.
|
25799371 |
2015 |
|
rs1045642
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggested that the MDR1 C3435T polymorphism may contribute to cancer risk.
|
22311042 |
2012 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was aimed to evaluate the possible effects of ABCB1 C3435T and ABCG2 C421A single nucleotide polymorphisms on clinical and pathological outcomes of Kurdish patients with breast cancer.
|
26700668 |
2016 |
|
rs1045642
|
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C3435T polymorphism of the ABCB1/MDR1 gene is not a risk factor for IBD, including UC and CD, in the population coming from central Poland.
|
22661185 |
2012 |
|
rs1045642
|
|
Leukopenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrhea; UGT1A1 (G-3156A)A/A (drug metabolism) was associated with IP-related neutropenia.
|
19349543 |
2009 |
|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
While, no remarkable relationship is observed between ABCB1 C3435T polymorphisms and UC.
|
25755800 |
2015 |
|
rs1045642
|
|
Drug Resistant Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we examined the impact of putatively functional polymorphisms 3435C>T and 2677G>T in the ABCB1 gene on the ABCB1 mRNA expression and P-gp content in human brain tissue from epileptogenic foci of the patients with refractory epilepsy.
|
18494787 |
2008 |
|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was conducted to find a possible reason for the discrepancies, and it was suggested that the age of onset was important for the association, namely, C3435T was predictive of susceptibility to later onset UC, but not for early onset UC.
|
16462040 |
2006 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients.
|
17674045 |
2008 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis provided evidence that MDR1 C3435T polymorphism is associated with a decreased risk of CRC in Asian population.
|
29390571 |
2017 |
|
rs1045642
|
|
Ulcerative Colitis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele frequencies and genotype distributions of the C3435T single nucleotide polymorphism were investigated in 149 patients with ulcerative colitis, 126 patients with Crohn's disease, and sex-matched healthy controls.
|
12512026 |
2003 |
|
rs1045642
|
|
Epilepsy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, but other ABC transporters are also thought to be involved in the transport of antiepileptic drugs.
|
19167193 |
2009 |
|
rs1045642
|
|
Crohn Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD).
|
17262810 |
2007 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy.
|
20638924 |
2010 |
|
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the T allele carrier of the 34</span>35 C/T polymorphism in the ABCB1 gene in combination with an estrogen receptor-negative status may be an important risk factor for breast cancer development in premenopausal women.
|
25730063 |
2015 |
|
rs1045642
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy.
|
20638924 |
2010 |
|
rs1045642
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer.
|
20127181 |
2011 |