|
rs505922
|
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNP rs505922, located within the first intron of the ABO gene, has been associated with the adenocarcinoma subtype of pancreatic cancer.
|
22642827 |
2012 |
|
rs505922
|
|
Alkaline phosphatase measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
IDENTIFYING GENETIC ASSOCIATIONS WITH VARIABILITY IN METABOLIC HEALTH AND BLOOD COUNT LABORATORY VALUES: DIVING INTO THE QUANTITATIVE TRAITS BY LEVERAGING LONGITUDINAL DATA FROM AN EHR.
|
27897004 |
2017 |
|
rs505922
|
|
Blood Protein Measurement
|
C |
0.700 |
GeneticVariation
|
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
rs505922
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together, these data suggest that the minor allele of rs505922 and the resulting non-O blood types are not associated with increased risk or less favorable tumor characteristics or prognosis in breast cancer.
|
22642827 |
2012 |
|
rs505922
|
|
C-reactive protein measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.
|
22291609 |
2012 |
|
rs505922
|
|
Cardioembolic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811).
|
23381943 |
2013 |
|
rs505922
|
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although rs505922 was not associated with LAA stroke (TT genotype, adjusted OR = 1.32; 95 % CI, 0.94 to 1.87), two novel SNPs, rs8176668 (AT genotype, adjusted OR = 0.71; 95 % CI, 0.55 to 0.92) and rs2073824 (AA genotype, adjusted OR = 0.72; 95 % CI, 0.57 to 0.92), were associated with LAA stroke.
|
26924317 |
2017 |
|
rs505922
|
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation
|
BEFREE |
Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811).
|
23381943 |
2013 |
|
rs505922
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
0.710 |
GeneticVariation
|
GWASCAT |
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
|
29358691 |
2018 |
|
rs505922
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.710 |
GeneticVariation
|
BEFREE |
These data indicate that the previously identified elevated risk of type 2 diabetes for carriers of the <i>ABO</i> rs505922:C allele may be caused by decreased early-phase insulin secretion.
|
31537524 |
2019 |
|
rs505922
|
|
Duodenal Ulcer
|
|
0.810 |
GeneticVariation
|
BEFREE |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
rs505922
|
|
Duodenal Ulcer
|
T |
0.810 |
GeneticVariation
|
GWASCAT |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
rs505922
|
|
Duodenal Ulcer
|
T |
0.810 |
GeneticVariation
|
GWASDB |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
rs505922
|
|
Graves Disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
|
23612905 |
2013 |
|
rs505922
|
|
Graves Disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
|
23612905 |
2013 |
|
rs505922
|
|
Homocysteine measurement
|
C |
0.700 |
GeneticVariation
|
GWASCAT |
Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke.
|
28495826 |
2017 |
|
rs505922
|
|
Infection caused by Helicobacter pylori
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABO (rs505922) and IL1B (rs1143627) may affect H pylori infection susceptibility, and IL1B (rs1143627) may also influence ID risk in infected children.
|
28727656 |
2018 |
|
rs505922
|
|
Invasive carcinoma of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the association between genetic variation in the ABO blood group and risk of breast cancer, rs505922 was genotyped in 629 Caucasian women with invasive breast cancer, representing a variety of clinical and pathological tumor types.
|
22642827 |
2012 |
|
rs505922
|
|
Iron deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABO (rs505922) and IL1B (rs1143627) may affect H pylori infection susceptibility, and IL1B (rs1143627) may also influence ID risk in infected children.
|
28727656 |
2018 |
|
rs505922
|
|
Ischemic stroke
|
|
0.720 |
GeneticVariation
|
BEFREE |
SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88-0.99, p = 0.023).
|
23381943 |
2013 |
|
rs505922
|
|
Ischemic stroke
|
|
0.720 |
GeneticVariation
|
BEFREE |
We found that rs579459 and rs505922 within ABO gene and their interaction were both associated with increased IS risk in Chinese population.
|
28984382 |
2018 |
|
rs505922
|
|
Ischemic stroke
|
C |
0.720 |
GeneticVariation
|
GWASCAT |
Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke.
|
28495826 |
2017 |
|
rs505922
|
|
Malaria
|
C |
0.700 |
GeneticVariation
|
GWASDB |
Imputation-based meta-analysis of severe malaria in three African populations.
|
23717212 |
2013 |
|
rs505922
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Together, these data suggest that the minor allele of rs505922 and the resulting non-O blood types are not associated with increased risk or less favorable tumor characteristics or prognosis in breast cancer.
|
22642827 |
2012 |
|
rs505922
|
|
Malignant neoplasm of pancreas
|
|
0.740 |
GeneticVariation
|
BEFREE |
SNP rs505922, located within the first intron of the ABO gene, has been associated with the adenocarcinoma subtype of pancreatic cancer.
|
22642827 |
2012 |