|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have also performed the haplotype analysis with val66met BDNF polymorphism, which is known to be involved in the pathogenesis of schizophrenia.
|
21710362 |
2012 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia.
|
26503495 |
2015 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the BDNF Val66Met polymorphism may affect a smoker's response to nicotine in both schizophrenia and healthy controls from a Chinese Han population, but with differential effects in different aspects of smoking behaviors.
|
25455509 |
2015 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) genetic polymorphisms with susceptibility to schizophrenia.
|
21641949 |
2011 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the BDNF Val66Met variant is not associated with response to antipsychotics in individuals with SCZ.
|
30181602 |
2019 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.
|
20430595 |
2010 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism results in reduced activity-dependent BDNF release and has been implicated in schizophrenia.
|
28864281 |
2018 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine, by meta-analysis, if the Val66Met polymorphism of BDNF influences risk for either schizophrenia, bipolar disorder, or both.
|
17417060 |
2007 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We argue that while the Val66Met polymorphism may not be a major risk-conferring agent for the development of schiz</span>ophrenia per se, there is mounting evidence that the polymorphism modulates a range of clinical features of the illness, including age of onset, symptoms, therapeutic responsiveness, neurocognitive function and brain morphology.
|
25562189 |
2015 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA methylation profiles were generated for CpG sites proximal to Val66Met, within BDNF promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects.
|
27712141 |
2017 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia.
|
20957650 |
2010 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single base pair polymorphism (BDNF Val66Met) was reported to be associated with AD and/or schizophrenia, as well as other psychoses, although some studies failed to replicate these findings.
|
21044653 |
2011 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
With the exception of nominally significant associations between BDNF Val66Met variation and PANSS total, negative, or general scores, no association between the BDNF Val66Met polymorphism and schizophrenia was found.
|
19359449 |
2009 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism.
|
15719396 |
2005 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This differential response to fetal hypoxia was specific to schizophrenia and was not explained by other obstetric complications or by the BDNF valine (val) to methionine (met) polymorphism at codon 66 (val66met).
|
18486103 |
2008 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism.
|
22362486 |
2012 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF G196A gene rs6265 polymorphism is not associated with the cognitive function but with the clinical symptoms of schizophrenia.
|
23923080 |
2013 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met genotyping was performed in 27 matched pairs of schizophrenia and comparison subjects.
|
16513879 |
2006 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-methyltransferase (COMT L) is associated with a deficit in attention and aggravation of delusions in schizophrenia.
|
18596619 |
2008 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia.
|
19714565 |
2010 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant association between BDNF Val66Met polymorphism and schizophrenia in our meta-analysis study.
|
26134309 |
2016 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task.
|
20708907 |
2010 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies have also shown that the BDNF Val66Met polymorphism was associated with weight gain in patients with schizophrenia on long-term antipsychotic treatment.
|
27483421 |
2016 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients.(PsycINFO Database Record
|
28857598 |
2018 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Data from several recent studies have also converged showing that the val66met allele of BDNF, a common single nucleotide polymorphism (SNP), is associated with selective minor deficits in cognitive functioning in subjects with schizophrenia, bipolar illness, and normal controls.
|
17239400 |
2007 |