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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects.
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23968401 |
2013 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression.
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27073970 |
2017 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.
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26462036 |
2015 |
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rs759834365
|
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Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression.
|
18852698 |
2010 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
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20515362 |
2010 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained.
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17482146 |
2007 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet.
|
29734099 |
2018 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects.
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21577214 |
2012 |
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rs759834365
|
|
Depressive disorder
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|
0.100 |
GeneticVariation
|
BEFREE |
According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024).
|
18450378 |
2008 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT.
|
29802070 |
2019 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness.
|
16043130 |
2005 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.
|
18263664 |
2008 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research.
|
17700574 |
2007 |
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rs759834365
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|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005).
|
17632285 |
2007 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Higher order interaction effects involving BDNF Val(66)Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness.
|
17579366 |
2008 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression.
|
24745471 |
2014 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma brain-derived neurotrophic factor (BDNF) concentration and the <i>BDNF</i> Val66Met polymorphism in suicide: a prospective study in patients with depressive disorder.
|
31308724 |
2019 |
|
rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
|
22033217 |
2012 |
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rs759834365
|
|
Depressive disorder
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|
0.100 |
GeneticVariation
|
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
|
26756166 |
2016 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
|
20220593 |
2010 |
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rs759834365
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke.
|
23399480 |
2013 |