|
rs1801516
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygote carriers of the G5557A variant were over-represented in RS-BC cases compared with non-RS-BC cases (OR, 6.76; 95% CI, 1.19-38.43).
|
14695186 |
2003 |
|
rs1801516
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygote carriers of the G5557A variant were over-represented in RS-BC cases compared with non-RS-BC cases (OR, 6.76; 95% CI, 1.19-38.43).
|
14695186 |
2003 |
|
rs1801516
|
|
Rectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
No associations were found between the IVS38-8 T/C, 5557 G/A and 5558 A/T polymorphisms and microhaplotypes in the ATM gene with respect to sporadic rectal cancer.
|
12827413 |
2004 |
|
rs1801516
|
|
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Based on the results, we propose a cancer risk-modifying effect for the ATM 5557G-->A, IVS38-8T-->C composite allele.
|
15756685 |
2005 |
|
rs1801516
|
|
Primary malignant neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
Based on the results, we propose a cancer risk-modifying effect for the ATM 5557G-->A, IVS38-8T-->C composite allele.
|
15756685 |
2005 |
|
rs1801516
|
|
bilateral breast cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
We discovered that the combination of 5557G-->A in cis position with IVS38-8 T-->C was associated with bilateral breast cancer (OR = 10.2; 95% CI = 3.1-33.8; p = 0.001).
|
15756685 |
2005 |
|
rs1801516
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results do not support association of the 5557G>A or ivs38-8T>C variant with increased breast cancer risk or with bilateral breast cancer.
|
16914028 |
2006 |
|
rs1801516
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results do not support association of the 5557G>A or ivs38-8T>C variant with increased breast cancer risk or with bilateral breast cancer.
|
16914028 |
2006 |
|
rs1801516
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this study suggest an association between the ATM codon 1853 Asn/Asp and Asn/Asn genotypes with the development of Grade 3 fibrosis in breast cancer patients treated with radiotherapy.
|
16338099 |
2006 |
|
rs1801516
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this study suggest an association between the ATM codon 1853 Asn/Asp and Asn/Asn genotypes with the development of Grade 3 fibrosis in breast cancer patients treated with radiotherapy.
|
16338099 |
2006 |
|
rs1801516
|
|
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Neither of the two common variants, 5557G>A and ivs38-8T>C, nor any haplotype containing them, was significantly associated with breast cancer risk, bilateral breast cancer or multiple primary cancers in any of the patient groups or subgoups.
|
16914028 |
2006 |
|
rs1801516
|
|
bilateral breast cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results do not support association of the 5557G>A or ivs38-8T>C variant with increased breast cancer risk or with bilateral breast cancer.
|
16914028 |
2006 |
|
rs1801516
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this study might suggest a minor association between polymorphism 5557G>A and a reduced risk of breast cancer.
|
18264724 |
2008 |
|
rs1801516
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IVS24-9 T/(-T), IVS38-8 T/C, 5557 G/A composite genotype confered a 3.19 fold increase in brea</span>st cancer risk (OR = 3.19 [95%CI 1.16-8.89], p = 0.021).
|
18433505 |
2008 |
|
rs1801516
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IVS24-9 T/(-T), IVS38-8 T/C, 5557 G/A composite genotype confered a 3.19 fold increase in brea</span>st cancer risk (OR = 3.19 [95%CI 1.16-8.89], p = 0.021).
|
18433505 |
2008 |
|
rs1801516
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this study might suggest a minor association between polymorphism 5557G>A and a reduced risk of breast cancer.
|
18264724 |
2008 |
|
rs1801516
|
|
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
The IVS24-9 T/(-T), IVS38-8 T/C, 5557 G/A composite genotype alone or in combination with certain genetic background and/or environmental factors, could modify the cancer risk by increasing genetic instability or by altering the effect of the normal DNA damage response.
|
18433505 |
2008 |
|
rs1801516
|
|
Primary malignant neoplasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
The IVS24-9 T/(-T), IVS38-8 T/C, 5557 G/A composite genotype alone or in combination with certain genetic background and/or environmental factors, could modify the cancer risk by increasing genetic instability or by altering the effect of the normal DNA damage response.
|
18433505 |
2008 |
|
rs1801516
|
|
Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We propose the three-hit hypothesis as a triangle initiators includes D1853N as a first predisposing hit, IVS 38- 63T --> A as a second hit deriving from the first somatic evolution before differentiation and IVS 38- 30 A --> G as a third hit through the development of an astrocytoma.
|
18465141 |
2008 |
|
rs1801516
|
|
Childhood Astrocytoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We propose the three-hit hypothesis as a triangle initiators includes D1853N as a first predisposing hit, IVS 38- 63T --> A as a second hit deriving from the first somatic evolution before differentiation and IVS 38- 30 A --> G as a third hit through the development of an astrocytoma.
|
18465141 |
2008 |
|
rs1801516
|
|
Medulloblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphism D1853N was reported in healthy individuals and medulloblastomas.
|
18465141 |
2008 |
|
rs1801516
|
|
Brain Tumor, Primary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three-hit hypothesis in astrocytoma: tracing the polymorphism D1853N in ATM gene through a pedigree of the proband affected with primary brain tumor.
|
18465141 |
2008 |
|
rs1801516
|
|
Papillary thyroid carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The ATM G5557A and XRCC1 Arg399Gln polymorphisms, regardless of radiation exposure, associated with a decreased risk of PTC according to the multiplicative and dominant models of inheritance (odds ratio (OR) = 0.69, 95% confidence interval (CI) 0.45-0.86 and OR = 0.70, 95% CI 0.59-0.93 respectively).
|
19286843 |
2009 |
|
rs1801516
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A statistically significant interaction of ATM D1853N and LIG4 C54T genotype with diabetes on the risk of pancreatic cancer was also detected.
|
19147782 |
2009 |
|
rs1801516
|
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
A statistically significant interaction of ATM D1853N and LIG4 C54T genotype with diabetes on the risk of pancreatic cancer was also detected.
|
19147782 |
2009 |