Source: CURATED

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs405509
rs405509
APOE
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study. 23100282

2013
dbSNP: rs405509
rs405509
APOE
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		0.700 GeneticVariation GWASDB Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. 23505291

2013
dbSNP: rs405509
rs405509
APOE
CUI: C0428474
Disease: Serum LDL cholesterol measurement
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs405509
rs405509
APOE
CUI: C0428474
Disease: Serum LDL cholesterol measurement
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. 22629316

2012
dbSNP: rs405509
rs405509
APOE
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs405509
rs405509
APOE
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs405509
rs405509
APOE
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. 22629316

2012
dbSNP: rs405509
rs405509
APOE
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.700 GeneticVariation GWASDB Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. 23103227

2012
dbSNP: rs405509
rs405509
APOE
CUI: C1272321
Disease: Autoantibody measurement
Autoantibody measurement 		0.700 GeneticVariation GWASDB Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900

2009
dbSNP: rs405509
rs405509
APOE
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.700 GeneticVariation GWASDB Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. 19060911

2009
dbSNP: rs405509
rs405509
APOE
CUI: C1862591
Disease: CORONARY ARTERY DISEASE, SEVERE, SUSCEPTIBILITY TO
CORONARY ARTERY DISEASE, SEVERE, SUSCEPTIBILITY TO 		T 0.700 SusceptibilityMutation CLINVAR

dbSNP: rs429358
rs429358
APOE
CUI: C0023980
Disease: Longevity
Longevity 		T 0.700 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies multiple longevity genes. 31413261

2019
dbSNP: rs429358
rs429358
APOE
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019
dbSNP: rs429358
rs429358
APOE
CUI: C0011269
Disease: Dementia, Vascular
Dementia, Vascular 		C 0.700 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019
dbSNP: rs429358
rs429358
APOE
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio 		T 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722

2019
dbSNP: rs429358
rs429358
APOE
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.700 GeneticVariation GWASCAT GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study. 31065058

2019
dbSNP: rs429358
rs429358
APOE
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		T 0.700 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422

2018
dbSNP: rs429358
rs429358
APOE
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010

2018
dbSNP: rs429358
rs429358
APOE
CUI: C0085220
Disease: Cerebral Amyloid Angiopathy
Cerebral Amyloid Angiopathy 		0.700 GeneticVariation GWASCAT Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. 29458411

2018
dbSNP: rs429358
rs429358
APOE
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010

2018
dbSNP: rs429358
rs429358
APOE
CUI: C4049938
Disease: Physical Activity Measurement
Physical Activity Measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE. 29899525

2018
dbSNP: rs429358
rs429358
APOE
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488

2018
dbSNP: rs429358
rs429358
APOE
CUI: C0020490
Disease: Hyperopia
Hyperopia 		C 0.700 GeneticVariation GWASCAT Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect. 30098192

2018
dbSNP: rs429358
rs429358
APOE
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010

2018
dbSNP: rs429358
rs429358
APOE
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		T 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531

2018