|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P<0.001), higher baseline proinsulin:insulin ratio (p<0.0001) and increased proinsulin:insulin ratio over a median of 2.5 years of follow-up (P = 0.003).
|
21814547 |
2011 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over an average period of three years, participants with the risk-conferring TT genotype at rs7903146 were more likely to have progression from impaired glucose tolerance to diabetes than were CC homozygotes (hazard ratio, 1.55; 95 percent confidence interval, 1.20 to 2.01; P<0.001).
|
16855264 |
2006 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
This result suggests that the increased health risk associated with rs7903146 genotype is specific to diabetes.
|
18437354 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated.
|
28299838 |
2017 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done.
|
21441683 |
2011 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
|
26914832 |
2016 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Concerned with predisposition for diabetes mellitus in obese children, we tested if risk genotypes TC and TT of rs7903146 are more common in obese children with increased homeostasis model assessment insulin resistance index (HOMA-IR) compared to obese controls with normal HOMA-IR.
|
18546086 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
There is a trend toward an association between faster GE and the diabetes-associated allele at rs7903146 in TCF7L2.
|
31691451 |
2020 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903146) for diabetes.
|
18268068 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes.
|
20839289 |
2010 |