|
rs451360
|
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We identified rs451360</span> as a novel SNP associated with lung cancer risk in the Chinese Han population.
|
25155038 |
2014 |
|
rs31489
|
|
Carcinoma of lung
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.
|
25422207 |
2014 |
|
rs401681
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
|
rs380286
|
|
Carcinoma of lung
|
|
0.710 |
GeneticVariation
|
BEFREE |
Further stratification analysis showed that rs380286 displayed a significantly decreased lung cancer risk (OR=0.65, P=0.041) in the non-drinkers.
|
25526467 |
2014 |
|
rs402710
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
|
rs451360
|
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
We identified that the minor alleles of rs451360, rs402710, and rs31484 in CLPTM1L were associated with a 0.52-fold, 0.76-fold, and 0.70-fold decreased risk of lung cancer in allelic model analysis, respectively.
|
25526467 |
2014 |
|
rs31484
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified that the minor alleles of rs451360, rs402710, and rs31484 in CLPTM1L were associated with a 0.52-fold, 0.76-fold, and 0.70-fold decreased risk of lung cancer in allelic model analysis, respectively.
|
25526467 |
2014 |
|
rs465498
|
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China.
|
26176862 |
2015 |
|
rs401681
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
rs380286
|
|
Carcinoma of lung
|
G |
0.710 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
|
28604730 |
2017 |
|
rs421629
|
|
Carcinoma of lung
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
|
28604730 |
2017 |
|
rs401681
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
|
rs401681
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer.
|
29033187 |
2017 |
|
rs401681
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs402710
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs401681
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs401681 polymorphism was significantly associated with a decreased risk of lung cancer, bladder cancer, and basal cell carcinoma in Asians and in hospital-based studies.
|
29254260 |
2017 |
|
rs401681
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
rs402710
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
rs380286
|
|
Carcinoma of lung
|
A |
0.710 |
GeneticVariation
|
GWASCAT |
Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.
|
31009812 |
2019 |