|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase).
|
20163778 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met genotype and 6-month remission rates in late-life depression.
|
20195291 |
2011 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
|
20220593 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF:rs6265 Met-allele was overrepresented in depression for women with problems during their childhood.
|
20226536 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity.
|
20346518 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders.
|
20515664 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
|
20667416 |
2011 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord.
|
20921572 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|
21037213 |
2010 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in d</span>epression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206.
|
21215389 |
2011 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects.
|
21577214 |
2012 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD).
|
21692988 |
2011 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction).
|
21880305 |
2011 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.
|
21996278 |
2012 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
|
22033217 |
2012 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
|
22610920 |
2012 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels.
|
22883353 |
2012 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.
|
22931410 |
2012 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs6265
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression.
|
23303061 |
2013 |