MTHFR-677TT genotype frequency was significantly higher in the acromegaly group than the control group (p=0.017), and a significant increase was found in fibrinogen (p=0.032) levels in 677TT-carrying acromegaly patients.
We investigated the influence of MTHFRC677T polymorphism, folate status and other lifestyle, nutritional and disease-specific variables on CRT risk in acromegaly.