|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After correcting for population structure, two haplotypes were found to confer risk of developing AD in a sex-specific manner: DLA-DRB1*015:01-DQA1*006:01-DQB1*023:01 in males (x<sup>2</sup>p = 0.03, OR 2.1) and DLA-DRB1*009:01-DQA1*001:01-DQB1*008:01:1 in females (x<sup>2</sup>p = 0.02, OR 8.43).
|
30968193 |
2019 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Montecarlo Exact Fisher Test demonstrated marked differences in all three Loci, DQA1, DQB1, DRB1 (p<0.0001) between AP versus both AITD and controls, as well as between AP type II (Addison's disease as major endocrine component) and AP type III (T1D + AITD).
|
31675055 |
2019 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dividing the APS collective into those with Addison's disease (APS type II) and those without Addison's disease but including type 1 diabetes and AITD (APS type III) demonstrated DR3-DQ2/DRB1*04:01-DQ8 as a susceptibility genotype in APS III (Pc<.001), whereas the DR3-DQ2/DRB1*04:04-DQ8 genotype correlated with APS II (Pc<.001).
|
24187405 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although not as profound as in US-AD, in SA-AD 21OH-AA + subjects the predominantly associated risk haplotypes were DRB1*0301-DQB1*0201 (DR3), DRB1*04xx-DQB1*0302 (DR4), and the combined DR3/4 genotype.
|
25040682 |
2014 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 404/DR4 is one of the genes involved in the development of Addison's disease in children with DMT1.
|
20857845 |
2010 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D.
|
19820007 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Particularly strong susceptibility for AD was found for the DR3-DQ2/ DRB1*0404-DQ8 genotype (odds ratio, 32; P = 4 x 10(-17)), which predicted early onset.
|
19858318 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*0403 was identified as a novel susceptibility allele for Addison's disease.
|
18057383 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk for Addison's disease was increased for the DR3-D6S273*140-MICA-A5.1/DRB1*0404-D6S273*134-MICA-A5.1 genotypes compared with that conferred by the DR3/4 controls.
|
12392510 |
2002 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with DRB1*0401 and DRB1*0402 have more limited progression to Addison's disease despite the presence of 21-hydroxylase autoantibodies.
|
9920103 |
1999 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among HLA-DR and -DQ haplotypes, only DRB1*03-DQA1*0501-DQB1*0201 (DR3/DQ2) was significantly more frequent in Addison's disease patients than in healthy subjects, but only in the presence of MIC-A5.1.
|
10523017 |
1999 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, identical gene markers were observed also in controls matched for DRB1*0301, thus suggesting that the patient group did not carry MHC gene segments specific for Addison's disease.
|
7860358 |
1994 |