| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Animal models of alcohol dependence and relapse demonstrate an important role of the glutamatergic system, in particular the cerebral metabotropic glutamate receptor 5 (mGluR5). | 31481578 | 2020 | ||||
|
0.070 | Biomarker | disease | BEFREE | Our findings elucidate a novel mGluR5-linked signaling state within BNST that plays a central and unanticipated role in excessive alcohol consumption.<b>SIGNIFICANCE STATEMENT</b> The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress and alcohol, and glutamate transmission within BNST is implicated in the neurobiology of alcoholism. | 30737312 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | The extracellular signal-regulated kinase (ERK<sub>1/2</sub>) pathway is downstream of mGluR5 and implicated in alcohol addiction; however, its role in sensitization remains unexplored. | 30914307 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | The present study was aimed to further characterize the pharmacological profile of N-[4-(trifluoromethyl) benzyl]-4-methoxybutyramide (GET73), a putative negative allosteric modulator (NAM) of metabotropic glutamate subtype 5 receptor (mGluR5) under development as a novel medication for the treatment of alcohol dependence. | 29674969 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | <b>Conclusion:</b> These findings provide human in vivo evidence that limbic mGlu5 has a role in the pathophysiology of alcohol dependence, possibly involved in a compensatory mechanism helping to reduce craving during abstinence. | 29348321 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | We found evidence of linkage disequilibrium between an AD-associated GABA receptor gene cluster, GABRB3/GABRG3, and eye color genes, OCA2/HERC2, as well as between AD-associated GRM5 and pigmentation-associated TYR. | 25921801 | 2015 | ||||
|
0.070 | Biomarker | disease | BEFREE | Replication analysis in study 2 confirmed an association of alcohol dependence with NR2A (odds ratio, 2.01) but showed no association with MGLUR5. | 18606955 | 2008 |