| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.340 | Biomarker | disease | BEFREE | The results of this study do not support alterations in the binding to NOP receptors in alcohol dependence. | 28711193 | 2018 | ||||
|
0.340 | Biomarker | disease | BEFREE | Together, these data suggest that small-molecule NOP agonists have the potential to reduce alcohol reward and may be promising as medications to treat alcohol addiction. | 29215139 | 2018 | ||||
|
0.340 | GeneticVariation | disease | BEFREE | To determine whether the nociceptin system is associated with alcohol or illicit drug dependence in humans, we analyzed 10 single nucleotide polymorphisms (SNPs) in OPRL1 and 15 SNPs in PNOC in a sample of 1923 European Americans from 219 multiplex alcohol dependent families ascertained by the Collaborative Study on the Genetics of Alcoholism. | 17910740 | 2008 | ||||
|
0.340 | GeneticVariation | disease | BEFREE | These findings suggest that genetic variants of the OPRL1 gene play a role in alcohol dependence in the Scandinavian population, warranting further investigation at the OPRL1 locus. | 18269382 | 2008 | ||||
|
0.340 | Biomarker | disease | PSYGENET | To determine whether the nociceptin system is associated with alcohol or illicit drug dependence in humans, we analyzed 10 single nucleotide polymorphisms (SNPs) in OPRL1 and 15 SNPs in PNOC in a sample of 1923 European Americans from 219 multiplex alcohol dependent families ascertained by the Collaborative Study on the Genetics of Alcoholism. | 17910740 | 2008 | ||||
|
0.340 | Biomarker | disease | PSYGENET | These findings suggest that genetic variants of the OPRL1 gene play a role in alcohol dependence in the Scandinavian population, warranting further investigation at the OPRL1 locus. | 18269382 | 2008 | ||||
|
0.340 | Biomarker | disease | PSYGENET | Although a large body of evidence suggests a role for the opioid system in alcoholism, the precise role of mu-, delta-, kappa-, and ORL1-opioid receptors and the physiological significance of their natural genetic variation have not been identified. | 15897716 | 2005 |