Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Brain aging and Alzheimer's disease both demonstrate the accumulation of beta-amyloid protein containing "plaques" and tau protein containing "tangles" that contribute to accelerated memory loss and cognitive decline. | 30728442 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. | 31653847 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | This study investigated if resveratrol (RES) can protect against cadmium chloride (CdCl<sub>2</sub>)-induced memory loss and Tau protein hyperphosphorylation in rats and explored its effect on AMPK/PI3K/Akt signaling pathway. | 30478674 | 2019 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | MAPT p.R406W carriers present clinically with progressive memory loss and neuropathologically with neuronal and glial tauopathy. | 30546007 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Alzheimer's disease (AD) is a neurodegenerative disorder characterized by loss of memory and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid-β peptide (Aβ) and neurofibrillary tangles formed of tau protein. | 25763997 | 2016 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | It is widely known that exogenous formaldehyde exposure induces human cognitive impairment and animal memory loss; and recent studies show that formaldehyde at pathological levels induces Aβ deposition and misfolding of tau protein to form globular amyloid-like aggregates. | 19879019 | 2011 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | To identify other neurotoxic tau protein species, we performed biochemical analyses on brain tissues from the rTg4510 mouse model and then correlated the levels of these tau proteins with memory loss. | 17409229 | 2007 |