Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE Using ordinal regression analysis, Asn-allele of NPSR1 polymorphism was nominally significantly associated with a lower risk of anxiety (OR = 0.57, CI: 0.33-0.97, p = .038) after adjusting for other covariates. 31132388 2019
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [rs324981" genes_norm="387129">asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms. 27990720 2017
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 Biomarker disease BEFREE These compounds are highlighted in this study as never being used as NPSR antagonists before which provides a model for the discovery of new bioactive inhibitors that may hold potential for drug development towards anxiety, food, and addiction disorders. 29055857 2017
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE In humans, associations between NPSR1 variants and anxiety and panic disorder, as well as amygdala responsiveness to fear- relevant faces and prefrontal cortex activity in a fear conditioning paradigm have been reported. 27883964 2017
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE Fronto-limbic connectivity varied between NPSR1 genotypes in the developing brain suggesting a risk-increasing effect of the NPSR1T allele for anxiety-related traits via impaired top-down control of limbic structures emerging during adolescence. 26503268 2017
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE Genes related to peptide and hormone signaling have been suggested for anxiety-related phenotypes, e.g., the NPSR1 gene, which has been associated predominantly with panic disorder in women, and shown to interact with environmental factors and to influence psychometric, neurophysiological, and neuroimaging correlates of anxiety. 26575296 2016
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE The association of single nucleotide polymorphisms of BDNF, NPSR1 and 5-HTT with anxiety and depression in asthamtic patients was evaluated. 27176146 2016
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 AlteredExpression disease BEFREE Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity. 25788677 2015
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE The present pilot data suggests NPSR1 gene variation to modulate Glx levels in the ACC during acute states of stress and anxiety, with blunted, i.e. possibly maladaptive ACC glutamatergic reactivity in T risk allele carriers. 26235955 2015
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 Biomarker disease BEFREE NPSR1 encodes the receptor for neuropeptide S (NPS) and NPS-NPSR1 signaling is involved in anxiety, inflammation, and nociception. 25091462 2014
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE Females with the functionally least active NPSR1 AA genotype and exposed to environmental adversity had affective/anxiety disorders more frequently; they also exhibited higher anxiety and depressiveness, and lower self-esteem. 24331455 2014
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders. 22404660 2014
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 Biomarker disease BEFREE Neuropeptide S and its receptor NPSR1 are involved in the regulation of arousal, attention and anxiety. 23325374 2014
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE The current results are in line with earlier imaging genetic studies and suggest a potential protective function of the NPSR1 rs324981 A/A genotype against pathologically enhanced anxiety that might be explained by stronger reflective prefrontal regulation over the subcortical fear response. 23103692 2013
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE In summary, the more active NPSR1 T allele may confer enhanced response inhibition and increased error monitoring and might drive particularly error monitoring as a neurophysiological endophenotype of anxiety as reflected by increased anxiety sensitivity. 23319044 2013
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 Biomarker disease BEFREE The neuropeptide S (NPS) and its receptor NPSR represent a transmitter system critically involved in the modulation of anxiety and arousal in rodents. 23466585 2013
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 GeneticVariation disease BEFREE Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety sensitivity. 21525857 2011
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 AlteredExpression disease BEFREE NPSR1 is expressed in the brain, where it modulates anxiety and responses to stress, but also in other tissues and cell types including lymphocytes, the lungs, and the intestine, where it appears to be up-regulated in inflammation. 20179762 2010
Entrez Id: 387129
Gene Symbol: NPSR1
NPSR1
0.100 Biomarker disease BEFREE The G protein-coupled receptor neuropeptide S receptor 1 (NPSR1) and its ligand neuropeptide S (NPS) form a signaling system mainly implicated in susceptibility to asthma and inflammatory disorders in humans and regulation of anxiety and arousal in rodents. 20705147 2010