Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease CTD_human Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats. 7589090 1995
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.300 Biomarker disease CTD_human Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. 22450443 2012
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.300 Biomarker disease CTD_human Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol. 16690336 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.300 Biomarker disease CTD_human Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction. 20131233 2010
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease CTD_human Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner. 26221077 2015
Entrez Id: 2182
Gene Symbol: ACSL4
ACSL4
0.300 Biomarker disease CTD_human Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis. 18988084 2008
Entrez Id: 196
Gene Symbol: AHR
AHR
0.300 Biomarker disease CTD_human The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway. 25194622 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.300 Biomarker disease CTD_human Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction. 20131233 2010
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.300 Biomarker disease CTD_human Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition. 15944321 2005
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.300 Biomarker disease CTD_human Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues. 25481498 2015
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.300 Biomarker disease CTD_human Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice. 21188452 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease CTD_human Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. 22450443 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.300 Biomarker disease CTD_human Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. 20974942 2010
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.300 Biomarker disease CTD_human In vivo exposure to hydroquinone during the early phase of collagen-induced arthritis aggravates the disease. 29935983 2018
Entrez Id: 1356
Gene Symbol: CP
CP
0.300 Biomarker disease CTD_human Ameliorating effect of Kalpaamruthaa, a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins. 19330884 2009
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
0.300 Biomarker disease CTD_human IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. 16713974 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease CTD_human Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice. 19765281 2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.300 Biomarker disease CTD_human Ameliorating effect of Kalpaamruthaa, a Siddha preparation in adjuvant induced arthritis in rats with reference to changes in proinflammatory cytokines and acute phase proteins. 19330884 2009
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.300 Biomarker disease CTD_human Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. 20974942 2010
Entrez Id: 847
Gene Symbol: CAT
CAT
0.300 Biomarker disease CTD_human Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. 22450443 2012
Entrez Id: 81567
Gene Symbol: TXNDC5
TXNDC5
0.300 Biomarker disease CTD_human Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis. 23326410 2013
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease CTD_human The effect of thalidomide and 2 analogs on collagen induced arthritis. 9598899 1998
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.300 Biomarker disease CTD_human Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. 15142272 2004
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.300 Biomarker disease CTD_human Twenty one days after induction of adjuvant arthritis, sciatic nerve levels of substance P were significantly increased whilst there was a small but non-significant increase in gamma-PPT mRNA and substance P in L4/L5 dorsal root ganglia (DRG). 9259450 1997
Entrez Id: 5734
Gene Symbol: PTGER4
PTGER4
0.300 Biomarker disease CTD_human MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. 18287210 2008